国内肺栓塞危险因素的Meta分析  

Meta-analysis of domestic risk factors for pulmonary embolism

作　　者：暨铭坚[1] 陈文利[1] 宫玉翠[1] 李平东[1] 

机构地区：[1]广州医科大学附属第一医院广州呼吸疾病研究所呼吸内科三区,510120

出　　处：《中国实用护理杂志》2014年第33期62-66,共5页Chinese Journal of Practical Nursing

摘　　要：目的 综合分析肺栓塞发病的危险因素,为临床的预防决策提供依据.方法 应用Meta分析的方法对国内有关肺栓塞发病危险因素的研究结果进行定量综合分析;运用RevMan5.2和Stata 12.0软件进行统计分析.结果 共纳入11篇研究文献,合计样本量1 459例,其中深静脉血栓形成（DVT）、恶性肿瘤、6周内手术史、长期卧床≥7 d和慢性阻塞性肺疾病（COPD）与肺栓塞相关,其合并OR值（95％CI）分别为10.41（4.54,23.87）、6.79（2.37,19.43）、2.63（1.12,6.19）、3.48（1.15,10.58）、2.36（1.45,3.84）.但尚不能认为既往血栓史、吸烟史与肺栓塞有关,其合并OR值（95％CI）分别为2.06（0.80,5.33）、1.57（0.87,2.82）.结论 长期卧床≥7 d、恶性肿瘤、DVT、6周内手术史和COPD均为肺栓塞发病的主要危险因素,应对肺栓塞高危人群进行早期干预.Objective To comprehensively analyze of risk factors for the incidence of pulmonary embolism,and provide the basis for the prevention of clinical decision-making.Methods Using Meta-analysis to find out the domestic risk factors of pulmonary embolism with a comprehensive analysis of the quantitative method,and RevMan 5.2 and Stata 12.0 software were used for statistical analysis.Results A total of 11 research literature was included,with a total sample size of 1 459 cases,including DVT,cancer,operation history within 6 weeks,long-term bedridden ≥ 7 d and COPD which were associated with pulmonary embolism,the pooled odd rate （95% CI） were 10.41 （4.54,23.87）,6.79 （2.37,19.43）,2.63 （1.12,6.19）,3.48 （1.15,10.58）,2.36 （1.45,3.84）.It could not be certain that past history of thrombosis and smoking history were related to pulmonary embolism,their pooled OR （95% CI） were 2.06 （0.80,5.33）,1.57 （0.87,2.82）.Conclusions Bedridden ≥ 7 d,cancer,DVT,operation history within 6 weeks and COPD are major risk factors for incidence of pulmonary embolism.Pulmonary embolism in high-risk groups should be dealt with early intervention.

关 键 词：肺栓塞 META分析 危险因素 

分 类 号：R563.5[医药卫生—呼吸系统]