胎盘蛋白13与胎盘生长因子联合检测对子痫前期患者的早期预测意义  

Significance of joint detection of placental protein-13 and placental growth factor in prediction of the preeclampsia during early pregnancy

作　　者：许香香[1] 冯一奇[1] 戴建荣[1] 

机构地区：[1]苏州市立医院本部妇产科,江苏苏州215007

出　　处：《中国计划生育和妇产科》2014年第8期24-26,共3页Chinese Journal of Family Planning & Gynecotokology

基　　金：苏州科技发展计划项目(项目编号:SYSD2010142)

摘　　要：目的评估外周血中胎盘蛋白13（placental protein-13,PP 13）与胎盘生长因子（placental growth factor,PLGF）联合检测对子痫前期（preeclampsia,PE）患者的早期预测意义。方法选择2010年8月至2013年2月苏州市立医院本部产前门诊建卡定期产前检查孕妇2 143名,202例PE孕妇为观察组,1 420例正常孕妇为对照组,采用酶联免疫吸附试验法（enzyme-linked immunosorbent assay,ELISA）检测血清PP13、PLGF的浓度,分析PP 13、PLGF单独和联合预测PE的灵敏度与特异度。结果观察组患者血清PP 13与PLGF水平均低于对照组,分别为[（48.12±12.40）vs（122.15±23.30）pg/m L]、[（54.50±17.17）vs（92.06±21.46）pg/m L],差异有统计学意义（P〈0.05）。ROC曲线结果显示孕11~13周,PP 13、PLGF中值倍（MOM）之和预测PE的发生,具有较高的灵敏度和特异度。结论孕早期PP 13与PLGF的联合检测对PE的发生有较好的预测价值。Objective To evaluate the significance of joint detection of placental protein- 13（ PP13） and placental growth factor（ PLGF） in prediction of preeclampsia（ PE） in early pregnancy. Methods 2143 pregnant women registered in Suzhou municipal hospital were chosen,202 cases with PE were selected into observation group,1420 normal pregnant women were selected into control group. The concentration of PP13 and PLGF were detected with the enzyme- linked immunosorbent assay（ ELISA）. The sensitivity and specificity of PP- l3 and PLGF for the prediction of PE were evaluated with the Receiver Operating Characteristic（ ROC） method. Results The difference of PP13[（ 48. 12 ± 12. 40） vs（ 122. 15 ± 23. 30） pg/m L]and PLGF [（ 54. 50 ± 17. 17）vs（ 92. 06 ± 21. 46） pg / m L] between two groups had statistical significance（ P〈0. 05）,ROC curve indicated that the sum of multiple of median（ MOM） of PP13 and PLGF were with high sensitivety and specificity for predicting PE. Conclusion The joint detection of PP13 and PLGF can effectively predict the preeclampsia（ PE） in early pregnancy.

关 键 词：胎盘蛋白13 胎盘生长因子 子痫前期 预测 

分 类 号：R714.244[医药卫生—妇产科学]