控制性超促排卵中溢乳症的临床处理分析  

Analysis of different clinical treatments on galactorrhea syndrome in controlled ovarian hyperstimulation

作　　者：戴芳芳 张丽晓[2] 郑波 郑晓红 程书清 许晓立 王春梅 

机构地区：[1]邢台不孕不育专科医院生殖中心,河北邢台054001 [2]邢台市人民医院中医科,河北邢台054001 [3]邢台市第一医院功能科,河北邢台054001

出　　处：《中国计划生育和妇产科》2014年第8期49-51,58,共4页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的探讨不同临床处理对体外授精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)中伴溢乳症的不孕症患者妊娠结局的影响。方法选择在邢台不孕不育专科医院生殖中心接受IVF-ET的不孕症患者358例,其中伴溢乳症296例,无溢乳症及基础血清催乳素(prolactin,PRL)正常的62例。按有无溢乳症、高PRL血症及其处理方法分为5组,A组为溢乳症不伴有高PRL血症,应用甲磺酸溴隐亭治疗;B组为溢乳症伴有高PRL血症,应用甲磺酸溴隐亭治疗;C组为溢乳症不伴有高PRL血症,应用中药治疗;D组为溢乳症不伴有高PRL血症,未给予药物治疗;E组为无溢乳症及基础血清PRL正常。比较5组不孕症患者外源性促性腺激素(gonadotropin,Gn)启动日PRL水平、注射绒毛膜促性腺激素(chorionic gonadotrophin,HCG)日PRL水平、获卵数、可用胚胎数、临床妊娠率。结果 5组不孕症患者比较,A组临床妊娠率最低(P<0.05);在Gn启动日和注射HCG日,A组PRL水平低于其他4组(P<0.05)。结论不孕症患者无高PRL血症的溢乳症状无需进行治疗,为改善症状,中药治疗可作为很好的尝试。Objective To investigate the impact of different clinical treatments on pregnant results in infertility patients underwent vitro fertilization embryo transfer（ IVF- ET） accompanying with galactorrhea syndrome. Methods 358 cases of infertility patients who underwent IVF- ET in The Repraduction Center of Xingtai Infertility Specialized Hospital were selected,of whom 296 cases were with galactorrhea syndrome,62 cases were of normal serum prolactin（ PRL） without galactorrhea syndrome. The patients were divided into 5 groups,Group A： patients of normal PRL with galactorrhea syndrome under treatment of bromocriptine mesilate,Group B： patients with hyperprolactinemia and galactorrhea syndrome under treatment of bromocriptine mesilate,Group C： patients of normal PRL with galactorrhea syndrome under treatment of traditional chinese medicine,Group D： patients of normal PRL with galactorrhea syndrome involving no treatment,Group E： patients of normal PRL without galactorrhea syndrome. PRL level at the start date of exogenous gonadotropin（ Gn）,PRL level at the day of injecting chorionic gonadotrophin（ HCG）,the number of oocyte,the number of available embryos and clinical pregnancy rate of 5 groups were compared. Results The clinical pregnancy rate of group A was the lowest（ P〈0. 05）,at the start date of Gn and the day of injecting HCG,the PRL level of group A was lower than that of the other 4groups（ P〈0. 05）. Conclusion There is no need of treatment for infertility patients with galactorrhea syndrome but of normal PRL,traditional chinese medicine can be used to improve symptoms.

关 键 词：溢乳症 体外授精-胚胎移植 控制性超促排卵 甲磺酸溴隐亭 中药 

分 类 号：R711.6[医药卫生—妇产科学]