N末端脑钠肽前体水平对预测窒息新生儿心肌损害的价值探讨  

Value of NT-proBNP level for predicting myocardial damage in asphyxia neonates

作　　者：苑文雯[1] 王晗[1] 耿伟[1] 何叶莉 朱剑功[1] 李沛然[1] 杨宁[1] 李妍[1] 郭桐生[1] 

机构地区：[1]解放军第三〇二医院临床检验医学中心,北京100039

出　　处：《检验医学与临床》2014年第22期3112-3113,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨血浆N末端脑钠肽前体(NT-proBNP)水平对窒息新生儿心肌损害及心功能的预测价值。方法选择该院住院治疗的窒息新生患儿36例作为观察组,其中23例轻度窒息,13例重度窒息;并选取同时期该院出生的36例健康新生儿作为健康对照组。对入选的儿童在其降生后72h内采集静脉血测定其血浆肌酸激酶同工酶(CK-MB)、肌红蛋白(Mb)和肌钙蛋白T(TnT)水平,同时测定NT-proBNP水平,对其进行对比分析。结果观察组中的重度窒息组患儿NT-proBNP、CK-MB、Mb、TnT各指标水平均明显高于轻度窒息组,差异有统计学意义(P<0.05)。观察组中各项指标水平变化随着窒息程度的增加而呈现递增趋势,且水平明显高于健康对照组,差异均有统计学意义(P<0.05)。结论 NT-proBNP水平对窒息新生儿心肌损害的预测具有明显的临床价值。Objective To investigate the predictive value of plasma N‐terminal brain natriuretic peptide（NT‐proBNP）level on myocardial damage in neonatal asphyxia .Methods 36 neonates with asphyxia in our hospital were selected as the observation group ,including 23 cases of mild asphyxia and 13 cases of severe asphyxia;at the same time 36 healthy neonates during the same period in this hospital were selected as the control group .The plasma crea‐tine kinase MB（CK‐MB） ,myoglobin（Mb）and troponin T （TnT ）levels in venous blood specimens within 72 h after birth from these enrolled neonates were measured ,and the NT‐proBNP level was simultaneously determined .The de‐tection results were performed the comparative anaysis .Results The NT‐proBNP ,CK‐MB ,Mb and TnT levels in the severe asphyxia group were significantly higher than those in the mild asphyxia group（P＆lt;0 .05） .The change of vari‐ous indexes levels in the observation group showed the ascending trend along with the asphyxia degree increase ,mo‐reover the levels in the observation group were significantly higher than those in the control group with statistical difference（P＆lt;0 .05） .Conclusion The NT‐proBNP level has significant clinical value in predicting the Mbcardial damage in neonates with asphyxia .

关 键 词：N末端脑钠肽前体 新生儿 窒息 心肌损害 

分 类 号：R563.5[医药卫生—呼吸系统]