干扰素γ释放试验诊断肺外结核的应用价值  

VALUE OF INTERFERON-GAMMA RELEASE TEST IN DIAGNOSING EXTRAPULMONARY TUBERCULOSIS

作　　者：贾晨光[1] 李秀武[1] 姚黎明[1] 刘建强[1] 黄俊 陈银芳 张雷 

机构地区：[1]河北省胸科医院骨科,河北石家庄050041 [2]武汉海吉力生物科技有限公司,湖北武汉430075

出　　处：《河北医科大学学报》2014年第10期1129-1131,共3页Journal of Hebei Medical University

基　　金：河北省科学技术研究与发展计划项目(12277754)

摘　　要：目的比较干扰素γ释放试验(interferon gamma release assay,IGRA)与结核菌染色涂片、结核菌培养、结核菌素试验(tuberculin skin test,TST)在肺外结核诊断中的敏感性,探讨IGRA方法在肺外结核中的应用价值。方法采集75例经临床诊断为肺外结核病患者的新鲜外周血,将IGRA检测结果与传统的检测方法(结核菌染色涂片、结核菌染色涂片培养、TST)的检测结果进行比较。结果 75例肺外结核患者中,IGRA检测阳性率为84.0%,结核菌染色涂片(8.0%),结核菌培养(5.3%),TST检测(52.0%),IGRA检测阳性率均明显高于其他临床常用检测方法,差异有统计学意义(P<0.01)。结论 IGRA试剂检测法诊断肺外结核,敏感性明显高于传统的检测方法,有很好的临床应用价值。Objective To compare the sensitivity of interferon gamma release test （IGRA） with suptum smear,sputum culture and tuberculin slcintest （TST ） in the diagnosis of extrapulmonary tuberculosis.To investigate the value of IGRA method in extrapulmonary tuberculosis.Methods Fresh peripheral blood samples were collected from 75 patients of clinically diagnosed extrapulmonary tuberculosis.The result was compared with those of traditional gold standard test methods （sputum smear and sputum culture,TST ）,and their clinical application value further were analyzed.Results In 75 cases of extrapulmonary tuberculosis,the positive rate by IGRA reagent test was 84.0%,sputum smear 8.0%,sputum culture 5.3%,TST test 52.0%.The positive rate of IGRA was significantly higher than those of other common methods,and the differences were statistically significant （P〈0.01）.Conclusion In the diagnosis of extrapulmonary tuberculosis,the sensitivity of IGRA reagent is significantly higher than those of the traditional test methods,IGRA has a good clinical value.

关 键 词：结核 干扰素γ释放试验 诊断 

分 类 号：R52[医药卫生—内科学]