2型糖尿病患者血清CA-125水平与代谢控制指标的相关性研究  

Correlation Study between the Level of Serum CA-125 and Controlling Indice of the Metabolism in Patients with Type 2 Diabetes Mellitus

作　　者：孟馨[1] 贾楠[1] 金智一 刘婷婷[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110001

出　　处：《中国医科大学学报》2014年第11期996-998,1002,共4页Journal of China Medical University

基　　金：辽宁省教育厅高校科研计划(L2011133);辽宁百千万人才工程人选资助项目(2012921033)

摘　　要：目的评估2型糖尿病患者血清CA-125水平与代谢控制指标的相关性。方法测定202例2型糖尿病住院患者血清CA-125水平,根据性别、糖化血红蛋白、血脂水平、体重指数(BMI)分组比较CA-125水平;分别计算性别、年龄、病程、BMI、腰围、血压、糖化血红蛋白、空腹血糖、血脂(TG、TC、LDL-C、HDL-C)、血尿酸与CA-125的相关性,并进行逐步多元回归分析比较各变量与CA-125的相关性。结果血清CA-125与糖化血红蛋白、空腹血糖、甘油三酯、总胆固醇水平呈正相关,与BMI、腰围呈负相关(P均<0.05)。多元逐步回归分析结果显示:糖化血红蛋白和甘油三酯是2型糖尿病患者血清CA-125升高的独立危险因素(P均<0.001)。结论 2型糖尿病患者糖脂代谢紊乱可影响CA-125水平,其中糖化血红蛋白和甘油三酯是CA-125升高的独立危险因素。Objective To analyze the relationship between CA-125 level and the controlling indice of the metabolism in patients with type 2 diabetes mellitus.Methods Serum CA-125 levels of 202 hospitalized patients with type 2 diabetes mellitus were measured,which were divided into different groups by sexuality,HbA1c,blood lipid and BMI.The levels of serum CA-125 among all the groups were compared and the relationship between sexuality,age,duration,BMI,waistline,blood pressure,HbA 1 C,FBG （fasting blood glucose）,blood lipid （TG,TC,LDL-C,HDL-C） and serum uric acid with CA-125 were analyzed.Furthermore,multiple stepwise regression analysis was performed to investigate the effect of different factors on CA-125 level.Results The HbA1C,FPB,TG and TC was positively related to the level of CA-125 （P ＜ 0.05） ; BMI and waistline was negatively related to the level of CA-125 （P ＜ 0.05） ; multiple logistic regression analysis showed that HbA1C and TG were the major factors for CA125 level in diabetic patients （P ＜ 0.001）.Conclusion The metabolism disorder of glucose and lipid affect serum CA-125 level,HbA1C and TG were the major factors for CA-125 level.

关 键 词：2型糖尿病 CA-125 糖化血红蛋白 体重指数 

分 类 号：R587.1[医药卫生—内分泌]