强骨饮对骨质疏松性股骨粗隆间骨折作用效果分析  

Effect of Qiangguyin on Osteoporotic Intertrochanteric Fractures

作　　者：叶健[1] 刘康[2] 黄余亮[2] 吴风晴 吴连国[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学附属第二医院,浙江杭州310005

出　　处：《中华中医药学刊》2014年第12期2912-2915,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局"十二五"重点学科建设项目(2012 32号);中国博士后科学基金项目(2013M530290);浙江省自然科学基金项目(LY12H27013)

摘　　要：目的:观察中药强骨饮对骨质疏松性股骨粗隆间骨折内固定术后患者骨代谢生化指标、骨密度及临床疗效的影响。方法:将符合本研究纳入标准的54例患者按入院顺序随机分为治疗组及对照组,治疗组27例,对照组27例。观察方法:治疗组行锁定钢板内固定术后予中药强骨饮及钙尔奇D口服治疗,对照组行锁定钢板内固定术后予口服钙尔奇D治疗,疗程为3月。术前和术后3月检测两组患者血清碱性磷酸酶(ALP)、抗酒石酸酸性磷酸酶(TRACP5b)及健侧股骨颈骨密度,并观察术后骨折愈合情况,记录患者Harris评分,所得数据进行统计分析。结果:54例入选病例有50例获得完整随访,治疗组25例,对照组25例。治疗组治疗后在骨折愈合率、骨代谢生化指标及骨密度值方面均优于对照组,差异有统计学意义(P<0.05);术后12月两组Harris评分数据比较,差异无统计学意义(P>0.05)。结论:中药强骨饮能改善骨质疏松性股骨粗隆间骨折患者骨代谢生化指标,提高骨密度,促进骨折的愈合。Objective： To observe the effect of traditional Chinese medicine Qiangguyin on osteoporotic intertrochanteric fracture. Methods： Patients with osteoporotic intertrochanteric fracture and met the inclusion criteria were randomly divided into treatment and control groups. After the operation,the patients in treatment group were administered with Qiangguyin and activated vitamin D while the others in control group were administered with activated vitamin D. The course of the treatment was 3 months. The serum levels of ALP and TRACP5 b were detected before the operation and 3 months after the operation. Bone healing was assessed with X- ray and bone mineral density（ BMD） was measured by dual energy X- ray absorption. We recorded the Harris hip score and the results were analyzed statistically. Results： A total of 50 patients completed the follow- up,including 25 patients in the treatment group and 25 patients in the control group. The？bone healing rate,bone metabolic biochemical markers and bone mineral density（ BMD） in the treatment group were better than those of the control group（ P〈0. 05）. The two groups showed no significant difference in Harris hip score（ P〈0. 05）. Conclusion： Traditional Chinese medicine Qiangguyin can improve bone metabolic biochemical markers,increase BMD and promote the fracture healing.

关 键 词：股骨粗隆间骨折 骨质疏松 锁定钢板 强骨饮 骨密度 

分 类 号：R274.1[医药卫生—中医骨伤科学]