隔药灸对胃癌化疗期间骨髓抑制保护作用的临床观察  

Protection of Herb-partitioned Moxibustion on Bone Mmarrow Suppression of Gastric Cancer Patients in Chemotherapy Period

作　　者：王建楠[1] 张卫星[2] 顾群浩[3] 矫健鹏[4] 刘龙[1] 魏品康[4] 

机构地区：[1]第二军医大学长海医院中医系,上海200433 [2]丽水市中医院,浙江丽水323000 [3]上海中医药大学附属岳阳中西结合医院,上海200437 [4]上海长征医院,上海200006

出　　处：《中华中医药学刊》2014年第12期2922-2925,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81102693;81102565);军队"十一五"中医药研发推广专项项目(2006171005)

摘　　要：目的:观察隔药灸对胃癌化疗期间骨髓抑制的临床疗效。方法:将72例胃癌患者随机分为治疗组35例和对照组37例,两组均予SOX方案化疗,治疗组化疗当天联用隔药灸,连用14 d,休息7 d,21 d为1个周期。2个周期后观察患者化疗后第3、7、14 d骨髓抑制情况,化疗后伴随症状评分及疗效及KPS评分。结果:两组患者的WBC、NEUT在治疗第3、7均较治疗前下降,治疗组的WBC显著高于对照组(P<0.05或P<0.01),治疗组第7 d的NEUT显著高于对照组(P<0.01);治疗第14 d,两组患者的WBC、NEUT均有升高趋势,治疗组WBC的升高程度由于对照组(P<0.05)。化疗后第3、7、14 d治疗组各分级骨髓抑制例数均显著少于对照组(P<0.05);治疗组化疗后第14 d各分级骨髓抑制例数显著少于第3 d骨髓抑制的患者例数(P<0.05)。化疗后14 d治疗组乏力、头晕及食欲减退改善均明显优于对照组(P<0.05或P<0.01)。治疗组KPS评分明显优于对照组(P<0.05)。结论:隔药灸可有效缓解化疗导致的骨髓抑制,在一定程度上缓解临床伴随症状,提高患者生活质量。Objective： To investigate the protection of herb-partitioned moxibustion on bone marrow suppression of patients with gastric cancer in chemotherapy period. Methods： Totally 72 gastric patients were randomized into the treatment group（ 35 cases） and control group（ 37 cases）. Both groups were given SOX chemotherapy. The patients in the treatment group were given herb-partitioned moxibustion at the same time with the chemotherapy beginning,for 14 days and following a latency of 7 days. One treatment course lasted for 21 days. Bone marrow suppression and associated symptoms and Karnofsky score（ KFS） were observed after two treatment courses. Results： The WBC count level in the treatment group on 3rd and 7th was higher than that in control group（ P〈0. 05 or P〈0. 01）. NEUT count level in the treatment group on 7th was higher than that in control group（ P〈0. 05 or P〈0. 01）. There was a rise trend on 14 th in the two groups,and the WBC count level in the treatment group was higher than that in control group（ P〈0. 05）. Compared with the control group,the bone marrow suppression degree decreased significantly in the treatment group on the 3rd,7th and14 th day of chemotherapy（ P〈0. 05）,and compared with the 3rd day,the bone marrow suppression degree decreased significantly on 14 th day in the treatment group. Comparing with the control group,the fatigue,dizziness and poor appetite were significantly relieved in the treatment group on the 14 th day of chemotherapy（ P〈0. 01 or P〈0. 05）. The scores of KPS in the treatment group were superior to those in the control group（ P〈0. 05）,and the score was increased with 13cases in treatment group compared with 3 cases in control group. Conclusion Herb-partitioned moxibustion is effective in inhibiting bone marrow suppression,relieving clinical symptoms and improving quality of life.

关 键 词：骨髓抑制 外治 中药治疗 隔药灸 

分 类 号：R245.8[医药卫生—针灸推拿学]