中药方剂联合纳洛酮对新生儿缺氧缺血性脑病疗效观察及安全性评价  

Efficacy and Safety Evaluation on Chinese Herbs Combined with Naloxone on Neonatal Hypoxic-Ischemic Encephalopathy

作　　者：肖荣玲[1] 张晨晖 

机构地区：[1]杭州市萧山区第一人民医院儿科 [2]温州市人民医院儿科

出　　处：《中华中医药学刊》2014年第12期2942-2944,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省自然科学基金项目(Y14H040005)

摘　　要：目的:探讨中药方剂联合纳洛酮对新生儿缺氧缺血性脑病疗效观察及安全性评价,为临床诊断治疗提供依据。方法:将114例新生儿缺氧缺血性脑病患儿根据随机数字表法将其随机分为治疗组(57例)和对照组(57例)。对照组给予纳洛酮治疗,治疗组在对照组治疗基础上服用中药方剂。两组均以14 d为1个治疗疗程,疗程结束后观察两组患者疗效及治疗前后NBNA评分。两组患儿一般资料结果对比显示无显著性差异(P>0.05)。结果:治疗组总有效率(92.98%)显著高于对照组(73.68%),且有显著性差异(P<0.05);两组患儿治疗前后NBNA评分比较差异无显著性(P>0.05);治疗组治疗后NBNA评分(36.18±2.05)显著高于对照组(27.68±2.96),且有显著性差异(P<0.05)。结论:中药方剂联合纳洛酮对新生儿缺氧缺血性脑病治疗疗效显著,且能够有效促进患儿神经功能恢复,同时还可改善其循环系统及呼吸系统,具有重要临床研究价值,值得临床推广应用。Objective： To investigate the efficacy and safety of TCM prescription combined with naloxone on neonatal hypoxic- ischemic encephalopathy and to provide the basis for clinical diagnosis and treatment. Methods： 114 cases of neonatal hypoxic- ischemic encephalopathy in children based on a random number table were randomly divided into treatment group（ n = 57） and control group（ n = 57）. The control group received naloxone treatment and the treatment group took TCM prescription on the basis of the control group. 14 d was a course of treatment. After treatment,we observed the efficacy and NBNA score. General results were compared in two groups and showed no significant difference（ P 0. 05）.Results： The total effective rate（ 92. 98%） was significantly higher than that of control group（ 73. 68%） and there was a significant difference（ P 0. 05）. NBNA scores of two groups of children before and after treatment showed no significant（ P 0. 05）. After treatment,NBNA score（ 36. 18 ± 2. 05） was significantly higher than that of control group（ 27. 68 ±2. 96） and there was a significant difference（ P 0. 05）. Conclusion： Chinese herbal formula combined with naloxone for the treatment of neonatal hypoxic- ischemic encephalopathy has significant effect and not only can effectively promote the recovery of neurological function in children but can also improve the circulatory system and respiratory system. It has important clinical research value and is worthy of application.

关 键 词：中药方剂 纳洛酮 新生儿 缺氧缺血性脑病 安全性评价 

分 类 号：R285.6[医药卫生—中药学]