栝楼果皮水溶性部位化学成分研究(英文)  

Chemical constituents from the water-soluble fraction of the peels of Trichosanthis Fructus

作　　者：李爱峰[1,2] 孙爱玲[2] 柳仁民[2] 张永清[1] 于京平[1] 

机构地区：[1]山东中医药大学药学院,济南250355 [2]聊城大学化学化工学院,聊城252000

出　　处：《中华中医药杂志》2014年第11期3420-3423,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：National Science and Technology Support Project(No.2011BAI06B00)~~

摘　　要：文章利用多种色谱技术(包括大孔吸附树脂柱色谱、反相柱色谱及制备型高效液相色谱)对瓜蒌皮水溶性部位的化学成分进行了系统的研究,得到9种化合物,利用紫外光谱、质谱及核磁共振波谱对化合物的结构进行了鉴定,分别为胞嘧啶(1)、尿嘧啶(2)、次黄嘌呤(3)、鸟嘌呤(4)、黄嘌呤(5)、腺嘌呤(6)、鸟嘌呤核苷(7)、6-异次黄嘌呤核苷(8)及腺嘌呤核苷(9),其中化合物1、3、4、5为首次从该植物中得到。In order to investigate the water-soluble constituents of the peels of Trichosanthis Fructus systematically, the separation and purification were performed by various chromatography methods including macroporous absorption resin column chromatography, reverse-phase column chromatography and preparative high performance liquid chromatography. Nine known compounds were isolated from the water-soluble fraction of the peels of Trichosanthis Fructus, and the structures were determined by spectroscopic analysis such as UV, MS and NMR spectrum. They were identified as cytosine （1）, uracil （2）, hypoxanthine （3）, guanine （4）, xanthine （5）, adenine （6）, guanosine （7）, 6-isoinosine （8） and adenosine （9）, among which compound 1, 3, 4, and 5 were isolated from this plant for the first time.

关 键 词：栝楼果皮 化学成分 水溶性部位 核苷 碱基 

分 类 号：R284[医药卫生—中药学]