血府逐瘀胶囊对AMI大鼠血清ICAM-1及肾脏组织ICAM-1 mRNA表达的影响  

Effects of Xuefu Zhuyu Capsule on the expression of serum ICAM-1 and ICAM-1 mRNA in renal tissues of AMI rats

作　　者：杜金行[1] 李腾飞[2] 宋威江[3] 廖江铨[3] 

机构地区：[1]中日友好医院,北京100029 [2]首都医科大学附属北京中医医院,北京100010 [3]北京中医药大学,北京100029

出　　处：《中华中医药杂志》2014年第11期3534-3536,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.81072924)~~

摘　　要：目的:观察血府逐瘀胶囊对大鼠心肌缺血后血清细胞间黏附分子-1(ICAM-1)含量及肾脏组织ICAM-1mRNA表达的影响。方法:将42只SD大鼠分为空白组8只、7d模型组8只、7d治疗组9只、14d模型组8只及14d治疗组9只,检测各组大鼠血清ICAM-1含量及肾脏组织ICAM-1 mRNA表达情况。结果:与空白组相比较,7及14d模型组大鼠血清ICAM-1含量及肾脏组织ICAM-1 mRNA表达均显著升高(P<0.01);经血府逐瘀胶囊治疗后,血清ICAM-1含量及肾脏组织ICAM-1 mRNA表达明显下降(P<0.05,P<0.01)。结论:大鼠急性心肌梗死后血清炎症因子ICAM-1和肾组织中炎性因子ICAM-1 mRNA表达升高,血府逐瘀胶囊治疗可抑制循环及肾脏局部组织炎性因子表达。Objective： To observe the effects of Xuefu Zhuyu Capsule on the expression of serum ICAM-1 and ICAM-1 mRNA in renal tissues of AMI rats. Methods： Forty-two SD rats were divided into five groups randomly： blank group （n=8）, 7 days model group （n=8）, 7 days treatment group （n=9）, 14 days model group （n=8） and 14 days treatment group （n=9）. Theexpressions of serum ICAM-1 and ICAM-1 mRNA in renal tissue were detected. Results： Compared with the blank groups, the content of serum ICAM-1 and the expression of renal tissue ICAM-I mRNA in 7 days and 14 days model group were significantly increased （P〈0.01）. Compared with the model groups, the content of serum ICAM-1 and the expression of renal tissue ICAM-1 mRNA in 7 days and 14 days treatment groups were significantly decreased （P〈0.05, P〈0.01）. Conclusion： The expression of ICAM-1 in serum and the inflammatory cytokine ICAM-1 mRNA in renal tissue are increased after acute myocardial infarction of rats. Xuefu Zhuyu Capsule can inhibit the expression of inflammatory factors in circulation and local kidney tissue.

关 键 词：活血化瘀法 血府逐瘀胶囊 细胞间黏附因子-1 信使RNA 

分 类 号：R285.5[医药卫生—中药学]