OSAHS与血栓前分子标记物及下肢静脉血栓相关性的研究  

Research on Relationship Between the Molecular Markers of Prethrombotic,Venous Thrombosis of Lower Extremities and Obstructiv Sleep Apnea Hyponea Syndrome

作　　者：吕秀云[1] 崔丽英[1] 成忠红[1] 

机构地区：[1]内蒙古医科大学附属医院呼吸内科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2014年第10期1156-1158,共3页Inner Mongolia Medical Journal

摘　　要：目的探讨OSAHS患者与血栓前分子标记物及下肢静脉血栓是否有相关性。方法对我院2010年至2011年所有诊断为OSAHS的580例患者进行分组,轻度患者为180例,中度为290例,重度为110例;健康对照组为50例。应用ELISA法对上述所有研究对象进行人凝血酶原片段F1+2、P-选择素、血浆抗凝血酶III(AT-III)、D-二聚体、血红蛋白(HGB)等检测和下肢静脉超声检查。结果 OSAHS患者组D-二聚体水平(μg/L)和血红蛋白(g/L)均高于健康组,而且随着病情的加重逐步升高。轻度组在P-选择素、人凝血酶原片段F1+2、血浆抗凝血酶III(AT-III)3项指标无明显差异,中度组及重度组均有差异。随着患者睡眠呼吸暂停低通气病情的加重,发生下肢静脉血栓的比例增高,轻度组中无1例发生下肢静脉血栓,中度组发生11例(11/180),重度组发生15例(15/110)。结论 OSAHS患者血栓前分子标记物高于健康人;阻塞性睡眠呼吸暂停低通气综合征与下肢静脉血栓有一定的关系。Objective To investigate the relationship between OSAHS and prethrombotic state and venous thrombosis of lower extremities（VTLE）. Methods the molecular markers of To compare the serum concentrations of F1 ＋ 2, P - selectin, AT- III, D- Dimer and HGB by ELISA method and venous ultrasound of the lower extremities in 180 mild OSAHS patients （mild group） and 290 moderate OSAHS patients（moderate group） and 110 severe OSAHS patients（severe group） and 50 normal people（normal group）. All 580 patients are diagnosed with OSAHS in the Affiliated Hospital of IMMU in 2010, 2011. ResuLt The levels of D - dimer and HGB in OSAHS patients were significant higher than those in normal group. There are no statistical difference between the normal group and mild group in the levels of F1 ＋ 2, P - seleetin, AT -III, but there are sig- nificant difference between the normal group and moderate and severe group. The proportion of VTLE is in- creasing with the aggravation of the OSAHS patients. There was none in mild group, but 11 in moderate group and 35 in severe group. Conclusion The levels of molecular markers of prethrombotic of OSAHS patients are higher than normal people, and OSAHS is related to VTLE.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 下肢静脉血栓 

分 类 号：R562.1[医药卫生—呼吸系统]