阿魏酸钠对弥漫性脑外伤大鼠血浆cGMP含量与听力变化的影响  

EFFECTS OF SODIUM FERULATE ON THE CONTENT OF cGMP IN PLASMA AND HEARING CHANGE WITH DIFFUSE TRAUMATIC BRAIN INJURY MODEL OF RATS

作　　者：邓艳丽[1] 刘建新[2] 张再兴[1] 顾洪兰[1] 卢鹤翔[3] 庞淑兰[4] 张萍[1] 付兴华[1] 

机构地区：[1]河北联合大学附属医院耳鼻喉科,河北省唐山市063000 [2]河北联合大学附属医院重症医学科 [3]河北联合大学形态中心 [4]河北联合大学公共卫生学院

出　　处：《中国煤炭工业医学杂志》2014年第11期1823-1826,共4页Chinese Journal of Coal Industry Medicine

基　　金：2012河北省医学科研重点项目计划(20120407)

摘　　要：目的探讨阿魏酸钠对弥漫性脑外伤大鼠血浆中环磷酸鸟苷含量及听力变化的影响。方法 SD大鼠随机分为正常组,生理盐水组,脑外伤组(伤后24h、72h、168h)及阿魏酸钠治疗组(24h、72h、168h)。在相应时间点上测试大鼠听性脑干反应及血浆环磷酸鸟苷的含量。结果脑外伤组血浆cGMP含量明显升高,与正常组、生理盐水对照组比较差异均有统计学意义(P<0.05);阿魏酸钠治疗组cGMP含量较脑外伤组下降,差异有统计学意义(P<0.05);脑外伤后各组ABR阈值及各波潜伏期与正常对照组比较差异有统计学意义(P<0.01);脑外伤后各组血cGMP含量与听力变化正相关,阿魏酸钠可影响脑外伤后各组大鼠ABR阈值及各波潜伏期,与血浆cGMP含量仍呈正相关。结论 DBI后大鼠血浆cGMP含量变化与听力损害可能有关,阿魏酸钠对DBI大鼠听力损害有一定保护作用。Objective To explore the effects of sodium ferulate on the content of cGMP in plasma and hearing change with diffuse traumatic brain injury model of rats.Methods Diffuse traumatic brain injury model of rats were established and randomly divided into four groups,including normal group,saline group,diffuse traumatic brain injury（DBI）model group and sodium ferulate treatment group.DBI group and treatment group also subdivided into groups of injury after twenty hours,seventy two hours and one hundred and sixty eight hours.Then auditory brainstem response and the content of cGMP in plasma were examined in different groups.Results The difference of cGMP content in plasma among the DBI group,the normal and saline group was obvious（P〈0.05）.In sodium ferulate treatment group,the content of cGMP was lower than that in DBI group,the difference was statistically significant（P〈0.05）;The difference of auditory brainstem response threshold and latency of wave between the experimental and the normal control group was obvious（P〈0.01）.There were some positive correlations between the the content of cGMP in plasma and the hearing changes in DBI group of different time sites.Sodium ferulate could affect ABR threshold and latency of each wave in DBI group,they were also positively correlated with the content of cGMP in plasma.Conculsion There maybe some relations between the changes of cGMP content in plasma and hearing impairment in DBI model of rats.Sodium ferulate has certain protective effect on hearing impairment in DBI rats.

关 键 词：弥漫性脑外伤 环磷酸鸟苷 听力 脑干听觉诱发电位 阿魏酸钠 大鼠 

分 类 号：R765.8[医药卫生—耳鼻咽喉科]