益气养阴、清热解毒散结法治疗中晚期非小细胞肺癌40例临床研究  

Clinical Observation on 40 Advanced Non-small Cell Lung Cancer Cases Treating by the Method of Supplementing Qi, Nourishing Yin, Clearing Heat, Removing Toxitant and Eliminating Stagnation

作　　者：王云启[1] 梁慧[1] 何欣[1] 陈铭[1] 

机构地区：[1]湖南省肿瘤医院,湖南长沙410013

出　　处：《中医药导报》2014年第15期17-20,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药管理局重点课题(2010006)

摘　　要：目的:观察益气养阴、清热解毒散结法治疗中晚期非小细胞肺癌(NSCLC)的疗效。方法:将80例NSCLC患者随机分为两组各40例。治疗组采用益气养阴、清热解毒散结法治疗,对照组采用最佳支持治疗。观察两组治疗后近期疗效、生活质量、体重、免疫指标的变化。结果:近期疗效获益率治疗组为65.0%,对照组为37.5%,两组比较,差异有统计学意义(P<0.05),治疗组近期疗效优于对照组;生活质量改善率治疗组为77.5%,对照组为52.5%,治疗组优于对照组,差异有统计学意义(P<0.05);两组治疗前后体重变化情况比较,治疗组优于对照组,差异有统计学意义(P<0.05);两组治疗后免疫功能比较,治疗组NK细胞数、IL-2、CD4+/CD8+等方面均优于对照组,差异有统计学意义(P<0.05)。结论:益气养阴、解毒散结法治疗中晚期非小细胞肺癌有较好近期疗效,可改善患者生存质量,增加患者体重,改善患者免疫功能。Objective： To observe the curative effects of treating on advanced NSCLC patients using traditional Chinese medicine of supplementing Qi, nourishing Yin, clearing Heat, removing toxitant and eliminating stagnation. Methods ： The Eighty patients were randomly divided into two groups, 40 in each. Patients were treated by Chinese medicine for supple-menting Qi, nourishing Yin, clearing Heat, removing toxitant and eliminating stagnation in treatment group, and the best sup-port treatment in control group. The changes of short-term curative effects, quality of life, weight and immune indexes were observed after the treatment. Results：The short-term curative effects of the treatment and control group were 65.0% and 37.5%respectively, with difference statistically（P〈0.05）, and the treatment group showed better the short-term curative effect than the control group. After treatment the rate of improvement on the quality of life was 77.5% for treatment group, while the control group was 52.5%, and the treatment group was better than that of control group, with statistical significance（ P〈0.05）. On body weight gaining, the treatment group was superior to the control group, with statistical significance（ P〈0.05）.The treatment group was better on moderating immune function than the control group on the aspects of the NK cells, IL-2, CD4^＋/CD8^＋, etc. And the difference was statistically significant（P〈0.05）. Conclusion： The traditional Chinese medicine of supplementing Qi, nourishing Yin, clearing Heat, removing toxitant and eliminating stagnation method in the treatment of advanced non small cell lung cancer has a better short-term effect, can improve the quality of life of patients, increase the patient＇s weight, and improve the immunity function of patients.

关 键 词：非小细胞肺癌 近期疗效 生活质量 免疫 益气养阴 解毒散结 中医 

分 类 号：R273[医药卫生—中西医结合]