生长抑素对糖尿病大鼠早期视网膜电图的影响  

Effect of somatostatin on early electroretinogram in diabetic rats

作　　者：孙亚东[1] 马彦[1] 姜艳静[1] 赵巧丹[1] 关红[1] 韩艳[1] 

机构地区：[1]吉林省人民医院内分泌科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2014年第6期1192-1196,共5页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅自然科学基金资助课题(201115205)

摘　　要：目的:探讨生长抑素对糖尿病(DM)大鼠早期视觉电生理改变的影响,阐明生长抑素对DM大鼠早期视网膜病变的治疗作用。方法:选取20只Wistar雄性大鼠作为研究对象,腹腔注射链脲佐菌素(STZ)诱导建立DM大鼠模型后,随机分为生长抑素治疗组和模型对照组,每组10只。生长抑素治疗组大鼠腹腔注射生长抑素10μg·kg-1·d-1,连续8周,模型对照组大鼠给予同体积生理盐水。另取Wistar雄性大鼠10只作为正常对照组。分别测定各组大鼠血糖及视网膜电图改变,并对各指标进行统计学分析。结果:与模型对照组比较,生长抑素治疗组大鼠8周时血糖水平下降(P<0.05)。与正常对照组比较,生长抑素治疗组与模型对照组大鼠1、2、4、6和8周时杆细胞反应、最大反应的a波和b波的潜伏期均延长(P<0.05),幅值于第6和8周时下降(P<0.05);与模型对照组比较,生长抑素治疗组大鼠8周时杆细胞反应、最大反应的a波和b波的潜伏期缩短(P<0.05),生长抑素治疗组各观察时间点幅值均无改变(P>0.05)。结论:生长抑素对于DM大鼠早期视网膜病变具有治疗作用。Objective To investigate the effect of somatostatin on the electrophysiological changes of early diabetic rats,and to clarify its therapeutic effects on retinopathy in early diabetic rats.Methods 20 Wistar male rats, which were induced into diabetic rat models by intraperitoneal injection of streptozotocin （STZ）,were randomly divided into somatostatin therapy group and model control group, 10 in each group.The rats in somatostatin therapy group were injected with somatostatin 10μg·kg-1 ·d-1,for 8 weeks;the rats in model control group received the same volume of saline.Another 10 male Wistar rats were used as normal control group.The changes of blood glucose and electroretinogram were measured, and the indicators were used for statistical analysis. Results Compared with model control group,the blood glucose was declined in somatostatin therapy group at the 8th week （P〈0.05）.Compared with normal control group,the latent periods of a-wave,b-wave of rod-response and max-response were significantly extended in somatostatin therapy group and model control group at the 1 st, 2nd,4th,6th,and 8th week （P〈0.05）.The latent periods of a-wave,b-wave of rod-response and max-response in somatostatin therapy group were shorter than those in model control group at the 8th week （P〈0.05 ）. Compared with model control group, the amplitude had no changes at each observation time point in somatostatin therapy group （P〉0.05）.Conclusion Somatostatin has a therapeutic effect on early diabetic retinopathy in rats.

关 键 词：生长抑素 糖尿病视网膜病变 视网膜电图 

分 类 号：R587.1[医药卫生—内分泌]