丹红注射液对急性脑梗死患者血液流变学及血清MMP-9、IGF-1含量的影响  

Effects of Danhong Injection on Hemorheology Indexes and MMP-9,IGF-1 in Patients with Acute Cerebral Infarction

作　　者：吴昌安[1] 费丰敏 

机构地区：[1]浙江省湖州市中医院,湖州313000 [2]浙江省湖州市第三人民医院,湖州313000

出　　处：《中国中医药科技》2014年第6期610-611,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：浙江省湖州市科技项目No.2012C33276

摘　　要：目的:观察丹红注射液对急性脑梗死患者血液流变学和血清基质金属蛋白酶(MMP-9)、胰岛素样生长因子-1(IGF-1)含量的影响。方法:将160例急性脑梗塞患者随机分为两组,对照组给予常规西药治疗,观察组在对照组的基础上加用丹红注射液;观察两组治疗前后血液流变学、血清MMP-9及IGF-1水平、神经功能缺损评分变化并评价临床疗效。结果:观察组各项指标改善均优于对照组,差异有统计学意义(P<0.05)。结论:丹红注射液治疗急性脑梗塞患者具有良好的临床疗效,其机理可能与其改善血液流变学指标、调节血清MMP-9、IGF-1合成与释放有关。Objective： To observe the effects of Danhong injection on hemorheology indexes and MMP-9,IGF-1 contents in patients with acute cerebral infarction. Methods： 160 patients were randomized into two groups： the control group were treated with conventional therapy,and the observation group were received Danhong injection based on routine treatment. Hemorheology indexes,MMP-9,IGF-1,neurological deficit scores and clinical efficacy were observed. Results： The total indexes of the observation group was better than those in the control group,the difference were statistically significant（ P 〈0. 05）. Conclusion： Danhong injection can improve the efficacy of patients with acute cerebral infarction,its mechanism may be related to the influence on hemorheology indexes and MMP-9,IGF-1 contents.

关 键 词：急性脑梗塞 丹红注射液 血液流变学 基质金属蛋白酶 胰岛素样生长因子-1 

分 类 号：R277.7[医药卫生—中医学]