归素膏对衰老小鼠皮肤SOD活性及MDA含量影响的实验研究  

Experimental Study on Effeets of Guisu Cream on SOD Activity and MDA Content in Senile Mice's Skin

作　　者：李凌霞[1] 赵晶[1] 党文军[1] 季顺欣[1] 李季委[1] 

机构地区：[1]黑龙江中医药大学佳木斯学院,佳木斯154007

出　　处：《中国中医药科技》2014年第6期637-638,共2页Chinese Journal of Traditional Medical Science and Technology

基　　金：黑龙江省中医药管理局资金资助课题No.ZHY12-2102

摘　　要：目的:观察归素膏对衰老小鼠皮肤超氧化物歧化酶(SOD)活力及丙二醛(MDA)含量的影响。方法:实验以自然衰老模型小鼠为研究对象,采用背部外搽给药方式,通过硫代巴比妥酸荧光比色法和黄嘌呤氧化酶法检测小鼠皮肤MDA含量和SOD活性。结果:空白对照组、当归组和染料木素组相比较,归素膏可显著提高衰老小鼠皮肤SOD活性,降低衰老小鼠皮肤MDA含量。结论:归素膏能够提高衰老小鼠皮肤SOD活性、降低皮肤中MDA含量,进而延缓机体皮肤衰老。Objective： To observe the effects of Guisu cream on super oxide dismutase（ SOD） activity and malondial dehyde（ MDA） content in senile mice＇s skin. Methods： The experiment took the natural aging mice as models,the route of medication was outside applied,glucosinolates barbituric acid fluorescence colorimetric method and xanthine oxidase method were applied to observe the MDA content and SOD activity. Results： To compare with control group,Guisu cream can significantly raise mice＇s skin SOD activity,decrease MDA content. Conclusion： Guisu cream have the function of improving SOD activity and reducing MDA content in senile mice＇s skin.

关 键 词：衰老 皮肤 归素膏 超氧化物歧化酶 丙二醛 小鼠(雌性) 

分 类 号：R285.5[医药卫生—中药学]