胡柚宝片剂对小鼠免疫功能影响的研究  

Studies on Effect of Huyoubao Tablet on Mice's Immunologic Function

作　　者：宋洁[1] 徐磊[1] 张春椿[1] 熊耀康[1] 

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《中国中医药科技》2014年第6期639-640,615,共3页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:观察胡柚宝片剂对小鼠免疫功能的影响。方法:根据《保健食品功能学评价程序和检验方法规范》中增强免疫功能试验方法,将胡柚宝片剂溶液0.4g/kg(LD)、0.8g/kg(MD)、1.6g/kg(HD)3个剂量灌胃小鼠,同时设空白对照组(蒸馏水),每天1次,10天后对实验小鼠进行脏器系数检测,并进行碳廓清试验和NK细胞活性检测。结果:3个剂量组小鼠的脾脏指数和胸腺指数均高于空白组,但均无显著性差异;其中低剂量组胸腺指数为最高。各组碳廓清指数变大,其中中剂量升高27%、高剂量升高40%,与空白组相比均具有显著性差异(P<0.05)。3个剂量组小鼠的NK细胞活性均高于空白组,与空白组比较,高剂量具有显著性差异(P<0.05,P<0.01)。结论:胡柚宝片剂具有增强小鼠免疫力功能。Objective： To observe the function of enhancing immunity of Huyoubao tablets in mice. Methods： According to the test method of strengthen the immune function in Health food function evaluation standard procedure and test Methods,giving the solution of Huyoubao tablets to mice once a day with the doses of 0. 4g /kg（ LD）,0. 8g / kg（ MD）,1. 6g / kg（ HD） for 10 days and established blank control group at the same time. Mice＇s spleen and thymus organ coefficient were tested,the indexes of the clearance rate of carbon and NK cell activity in mice were determined. Results： Mice＇s spleen and thymus organ coefficient were all higher than those of the blank control group,but had no significant difference,thymus organ coefficient was the highest in low dose. The indexes of carbon clearance were raised,that middle dose was roised 27% while high dose was raised 40%,which compared with the blank group has significant difference（ P〈0. 05,P〈0. 01）. the activity of NK cells in the three doses mice were all higher than that of the blank control group,moreover,the high dose had significant difference to compare with the blank control group（ P〈0. 05,P〈0. 01）. Conclusion： Huyoubao tablets has the ability of enhancing immune function.

关 键 词：胡柚宝片剂 免疫功能 小鼠 

分 类 号：R285.5[医药卫生—中药学]