C反应蛋白与自身免疫性疾病  

C-reactive protein and autoimmune diseases

作　　者：韩杨[1] 崔天盆[1] 程贵莲 万彬彬[3] 

机构地区：[1]武汉市第一医院检验科,430022 [2]湖北中医药大学检验学院 [3]武汉市第一医院风湿免疫科,430022

出　　处：《中华检验医学杂志》2014年第11期876-878,共3页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金面上项目（81170035）;湖北省自然科学基金项目（2010CDB08903）

摘　　要：凋亡细胞清除缺陷在自身免疫性疾病的发病中有重要作用，C反应蛋白（ CRP）与死亡或受损细胞上的磷酸胆碱及相关分子结合，具有重要免疫调节功能。 CRP作为可溶性调理素通过活化补体和（或）与免疫球蛋白受体FcγR结合，促进病原体和凋亡细胞或核抗原清除，防止自身免疫病的发生，因此CRP在自身免疫和炎性疾病中有重要作用，临床上CRP水平也是一个敏感的自身免疫和炎性反应指标，可用于活动性自身免疫病的评估和诊断。Impaired clearance of apoptotic cells is important in the pathogenesis of autoimmune disease.C-reactive protein （CRP） is an acute phase protein that plays a major role in the regulation of the autoimmune and inflammatory response .CRP has a role in the clearance of bacteria and dying and altered cells through binding to phosphocholine and might also have more complex immunomodulatory functions . CRP function as opsonins for pathogens and dying and apoptotic cells through activation of the complement pathway and through binding to Fcγreceptors , and is associated with the clearance of apoptotic cells and nuclear antigen , thus becoming a protective molecule against pathogenic autoimmune responses in general . Measurement of serum CRP level is in widespread clinical use as a sensitive marker of inflammation and autoimmune disease , particularly in relation to the use of the CRP-based disease activity score in the evaluation of rheumatoid disease.

关 键 词：C反应蛋白质 自身免疫疾病 细胞凋亡 

分 类 号：R593.2[医药卫生—内科学]