MicroRNA与糖尿病肾病  

The progress of Micro RNA in diabetic nephropathy

作　　者：王晓莉[1] 覃建阳[2] 滕玲[2] 尹昌浩[3] 

机构地区：[1]牡丹江医学院红旗医院肾内科,黑龙江牡丹江157011 [2]牡丹江医学院附属二院,黑龙江牡丹江157009 [3]牡丹江医学院红旗医院神经内一科,黑龙江牡丹江157011

出　　处：《解剖科学进展》2014年第6期567-570,共4页Progress of Anatomical Sciences

基　　金：黑龙江省卫生厅科研课题资助(No.2011-304)

摘　　要：糖尿病肾病是糖尿病最常见的慢性并发症之一,Micro RNA通过调控细胞外基质蛋白合成、肾小管上皮-间充质转分化及足细胞功能参与糖尿病肾病的发生。此外,它们可作为潜在的糖尿病的生物标志物和治疗靶点。本文针对Micro RNA在糖尿病肾病方面的研究进展做一综述,目的在于从分子水平为糖尿病肾病的诊断和治疗提供新的思路和研究方向。Diabetic nephropathy is one of the most common chronic complications of diabetes mellitus. MicroRNAs are involved in the pathogenesis of diabetic nephropathy through the regulation and control of extracellular matrix protein synthesis, epithelial-mesenchymal transition and the function of sertoli cell, in addition, they can be used as potential biomarkers and therapeutic targets for the diabetes. The paper would provide new train of ideal and research direction for the diagnosis and treatment of diabetic nephropathy at the molecular level.

关 键 词：糖尿病肾病 MICRORNA 转分化 间充质 肾小球系膜 生物标志物 细胞因子 高血糖 细胞外基质蛋白 寡核苷酸链 

分 类 号：R587.1[医药卫生—内分泌]