低氘白酒对人体心率变异性和自主神经的调控作用  

Effects of deuterium-depleted Chinese liquor on heart rate variability and autonomic nervous system

作　　者：夏红蕾[1] 石路[2,3] 沈才洪[4] 刘洪涛[3] 周军[4] 曾娜[4] 刘世龙[4] 李云辉[4] 丛峰松[1] 

机构地区：[1]上海交通大学生命科学技术学院,上海200240 [2]上海交通大学上海交通大学-千叶大学国际合作研究中心,上海200240 [3]上海交通大学海洋水下工程科学研究院,上海200231 [4]国家固态酿造工程技术研究中心,泸州老窖股份有限公司,四川泸州646000

出　　处：《生物医学工程与临床》2014年第6期528-531,共4页Biomedical Engineering and Clinical Medicine

基　　金：国家自然科学基金资助项目(81272478)

摘　　要：目的研究连续8 d急性摄入不同剂量自制酒精饮料、传统白酒和低氘白酒对人体心率变异性（HRV）和自主神经调控作用。方法 11例健康成年男性志愿者,体质量（64.7±4.5）kg,年龄21~25岁,平均年龄23.7岁。分为7个试验组,①本底（对照）（CK组）,不饮用任何含酒精饮品;②低剂量酒精（A-L组）,每天饮用50 m L 52度自制酒精＋200 m L普通饮用水;③高剂量酒精（A-H组）,每天饮用100 m L 52度自制酒精＋200 m L普通饮用水;④低剂量白酒（L-L组）,每天饮用50 m L52度泸州老窖特曲＋200 m L普通饮用水;⑤高剂量白酒（L-H组）,每天饮用100 m L 52度泸州老窖特曲＋200 m L普通饮用水;⑥低剂量低氘白酒（DDL-L组）,每天饮用50 m L 52度泸州老窖特曲＋200 m L低氘水;⑦高剂量低氘白酒（DDL-H组）,每天饮用100 m L 52度泸州老窖特曲＋200 m L低氘水。连续8 d。用心动周期信号（HPS）分析系统检测饮酒半小时后受试者的HRV,以评价交感神经和副交感神经系统活动。结果饮用自制酒精饮料和传统白酒使自主神经的交感神经活性及迷走神经活性变化,以交感神经活性升高最为突出活性。饮用低氘白酒后未见有交感和迷走神经活性的明显变化,即HRV的波动。结论相对于自制酒精饮料和传统白酒,低氘白酒能使人体自主神经协调和平衡性维持在较高水平。Objective To study the effect of deuterium-depleted Chinese liquor on heart rate variability（HRV）, and evaluate the regulation of autonomic nervous system activity for cardiac function. Methods A total of 11 healthy adult male were enrolled, aged21- 25 years old with mean age of 23.7, and body weight（64.7 ± 4.5） kg. The study was divided into 7 groups： ①control group（CK）,without any alcoholic beverages; ②low-dose alcohol group（A-L）, every day drinking 50 m L 52 degrees self-made alcohol ＋ 200 m L water; ③high-dose alcohol group（A-H）, every day drinking 100 m L 52 degrees self-made alcohol ＋ 200 m L water; ④low-dose ordinary Chinese liquor group（L-L）, every day drinking 50 m L 52 degrees Luzhoulaojiao ＋ 200 m L water; ⑤high dose ordinary Chinese liquor group（L-H）, every day drinking 100 m L 52 degrees Luzhoulaojiao ＋ 200 m L water; ⑥low-dose deuterium-depleted Chinese liquor group（DDL-L）, every day drinking 50 m L 52 degrees Luzhoulaojiao ＋ 200 m L deuterium-depleted water; ⑦high-dose deuterium depleted Chinese liquor group（DDL-H）, every day drinking 100 m L 52 degrees Luzhoulaojiao ＋ 200 m L deuterium-depleted water. The test was performed serial 8-day, the Biopac MP30 system was adopted to collect data of HRV 30- 45 minutes after drinking and sympathetic and parasympathetic nervous systems were evaluated. Results The self-made alcoholic and traditional liquor made sympathetic atomic nerve activity and changed parasympathetic, the most was sympathetic nerve, but there was no significant changed in deuterium-depleted Chinese liquor. Conclusion It is demonstrated that the deuterium-depleted Chinese liquor is useful to maintain the balance of cardiac sympathetic and parasympathetic autonomic nervous to the certain degree.

关 键 词：低氘白酒 心率变异性 交感神经 副交感神经 

分 类 号：R54[医药卫生—心血管疾病]