基于弥散图像人丘脑连接的无创性显示和分析  

Non-invasive showing of the connections of the human thalamus using diffusion imaging

作　　者：陈一勇[1] 尹维刚[1] 林荣[1] 丁杰[1] 王守道[1] 汪海清[1] 李林[2] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]南京医科大学解剖学教研室,南京210029

出　　处：《中国临床解剖学杂志》2014年第6期671-675,共5页Chinese Journal of Clinical Anatomy

基　　金：宁波市自然科学基金(2014A610233)

摘　　要：目的显示和分析人丘脑与端脑额叶、顶叶、颞叶、枕叶、基底核及边缘系统等的连接情况。方法联合应用DSI-studio和Brian Suite软件对10例脑连接组项目(HCP,Human Connectome Project)提供的磁共振弥散和T1加权数据进行处理,通过纤维束重建、脑结构配准、纤维束连接分析等过程,显示丘脑与脑其它结构连接情况。结果 (1)通过纤维束三维重建可见丘脑可通过其额脚、顶脚、颞脚和枕脚与端脑相应区域连接;(2)在Brian Suite软件生成的脑连接分析图上可详细得到左右两侧丘脑与额叶、顶叶、颞叶、边缘系统、基底核等区域的具体连接情况。结论我们提供了一种研究丘脑连接的新的方法,可为后续的丘脑相关功能和临床学研究提供结构和方法学上的帮助。Objective To show and analyze the structural connectivity perspective of the thalamus. Methods 10 High-resolution structural images（T1w） and High Angular Resolution Diffusion Imaging （HARDI） data sets from Human Connectome Project（HCP） were acquired and analyzed. The connectivity perspective of thalamus, the tractography, registration of the brain structure were demonstrated and analysis of the connectivity was performed using DSI-Studio and BrainSuite software, Results （1） 3-dimensional images showingthe anterior, superior, posterior and inferior thalamic peduncles can be obtained using the DSI- studio software and BrainSuite software. （2） The structural connectivity between human thalamus and the other parts of the brain was shown using the BrainSuite software. Conclusion High-resolution T1 images and high angular resolution diffusion imaging data from HCP can be used to study the structural connectivity of the human thalamus; furthermore, the results can provide the basis for clinical research of thalamus.

关 键 词：脑连接组项目 DSI-studio软件 Brian Suite软件 丘脑 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]