MicroRNAs与系统性红斑狼疮发病机制相关性的研究进展  

A System Review on the Association between MicroRNAs and the Pathogenesis of Systemic Lupus Erythematosus

作　　者：刘璐[1] 闻雷雷[1] 崔勇[1] 

机构地区：[1]安徽医科大学皮肤病研究所、安徽医科大学第一附属医院皮肤性病科,安徽合肥230032

出　　处：《中国皮肤性病学杂志》2014年第12期1285-1287,共3页The Chinese Journal of Dermatovenereology

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种自身免疫性疾病,以产生针对多种器官的自身抗体为特点。MicroRNAs(miRNAs)是一种非编码的单链小分子RNAs,主要参与基因转录后水平的调控。miRNAs作为转录调节器参与SLE的发病环节。本文主要从DNA低甲基化、Ⅰ型干扰素通路、调节性T细胞、雌激素四个方面,对miRNAs与SLE发病机制相关性及其研究进展进行综述。Systemic lupus erythematosus （SLE） is a prototypic autoimmune disease, characterized by the production of autoantibodies against multiple organs. MicroRNAs （miRNAs） are non-coding, single-stranded small RNAs that post-transcriptionally regulate gene expression. MiRNAs is involved in the pathogenesis of SLE as a transcriptional regulator. This review discussed the association between the role of miRNAs and the pathogenesis of SLE, with focus on the DNA hypomethylation, type Ⅰ interferon pathways, regulatory T cells, and estrogen, as well as new research issues in these fields.

关 键 词：MICRORNAS 自身免疫 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]