羊膜移植对外伤复发性角膜上皮糜烂疗效  

Clinical effect of amniotic membrane in treating secondary recurrent corneal erosions caused by corneal abrasion

作　　者：谢敏[1] 赵敏[2] 羊薇[1] 唐晨[1] 朱晓虹[1] 

机构地区：[1]德阳市人民医院眼科,四川618000 [2]重庆医科大学附属第一医院眼科,重庆400016

出　　处：《中国实用眼科杂志》2014年第11期1357-1359,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的 探讨羊膜移植治疗外伤所致复发性角膜上皮糜烂的临床疗效.方法 对2006年1月至2013年6月在德阳市医院眼科就诊的13例（13只眼）轻微外伤所致的经药物治疗无效、反复发作的复发性角膜上皮糜烂患者,采用角膜上皮清创＋羊膜移植治疗,术后观察视力、角膜透明度及荧光素染色情况、羊膜转归、病变复发情况以及并发症.结果 术后3～5 d羊膜即开始出现部分融解,1～2周大部分脱落;羊膜脱落后病人视力均较术前提高,裂隙灯检查见角膜基本恢复透明,上皮完全修复,荧光素染色阴性.经6～83个月临床观察,除1例在术后4月出现复发外,其余12例均未再复发;未见明显并发症发生.结论 对于常规治疗方法无效的复发性角膜上皮糜烂患者,羊膜移植是一种安全有效、低费用的治疗方法.Objective To investigate the clinical effects of amniotic membrane transplantation in treating secondary recurrent corneal erosions caused by corneal abrasion.Methods Thirteen eyes of 13 patients with secondary recurrent corneal erosions caused by corneal abrasion that were resistant to various conventional medications underwent corneal epithelium debridement,and amniotic membrane transplantation.Postoperative examinations were conducted for visual acuity,corneal transparency,fluorescein staining,amniotic membrane turnover,recurrence,and complications.Results Amniotic membrane started to dissolve in 3-5 days after operation,and most of it fell off within 1-2 weeks.Thereafter,patients＇ visual acuity was markedly improved.Slit-lamp examinations showed that the corneal turned transparent,the epithelium recovered,and the fluorescein staining were negative.After a follow-up time of 6-83 months,12 of 13 eyes （92.31％） healed with no complications; only one eye experienced a recurrence in four months.Conclusions Amniotic membrane transplantation is a safe,effective,and low-cost treatment for those who suffer from recurrent corneal eros ionsthat are resistant to various conventional medications.

关 键 词：复发性角膜上皮糜烂 羊膜移植 

分 类 号：R978.21[医药卫生—药品]