苯妥英钠对华法林血药浓度的影响  

Effects of phenytoin on plasma concentration of warfarin

作　　者：郭雪松[1] 肖凤[1] 

机构地区：[1]四川省攀枝花市中心医院药学部,四川攀枝花617067

出　　处：《海南医学院学报》2015年第1期21-23,共3页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(30973087)~~

摘　　要：目的:探讨苯妥英钠对华法林血药浓度的影响,为临床合理用药提供依据。方法:25只大鼠随机分为对照组及苯妥英钠2、5、8、11mg/kg组,每天上午给各组大鼠灌华法林,下午灌生理盐水或苯妥英钠,第2、4、6天分别取血样检测药效学指标凝血酶原时间(PT)和活化部分凝血活酶时间(APTT),第7天后取血样用高效液相色谱测定体内华法林的血药浓度。结果:2mg/kg组苯妥英钠与华法林对照组比较,华法林体内血药浓度无统计学意义(P>0.05),苯妥英钠5、8、11mg/kg组有统计学意义(P<0.05),苯妥英钠各剂量组组间比较,均具有统计学意义(P<0.05)。结论:给药浓度为5mg/kg的苯妥英钠可使大鼠体内华法林浓度上升,且随着苯妥英钠给药浓度的增大,抑凝血作用越强,呈现浓度依赖性。Objective：To explore effect of phenytoin on plasma concentration of warfarin.Methods：Sixty mice were randomly divided into five groups：control group and phenytoin 2mg/kg,5mg/kg,8mg/kg and 11mg/kg groups.All mice were given with orally warfarin in the morning,phenytoin or physiologic saline in the afternoon.The plasma concentration was determined after seven days with HPLC.Results：Compared to the control group,there was no significant difference in plasma warfarin concentration of phenytoin 2mg/kg group（P〉0.05）,and the differences of phenytoin 5 mg/kg,8 mg/kg and 11mg/kg groups were significant（P〈0.05）.There were significant differences among three phenytoin groups（P〈0.05）.Conclusions：Phenytoin 5mg/kg can increase warfarin plasma concentration in mice.Furthermore,increase of hemagglutination inhibition by warfarin depends on the dosage of phenytoin.

关 键 词：华法林 苯妥英钠 药效学 血药浓度 

分 类 号：R917[医药卫生—药物分析学]