阿托伐他汀联合苯磺酸氨氯地平治疗冠心病合并脑梗死的临床效果  

Clinical effect of atorvastatin and amlodipine benzene in treatment of coronary heart disease complicated with cerebral infarction

作　　者：余广兰[1] 

机构地区：[1]宜宾市第一人民医院神经内科,四川宜宾644000

出　　处：《海南医学院学报》2015年第1期29-31,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金资助项目(11220266)~~

摘　　要：目的:研究阿托伐他汀联合苯磺酸氨氯地平治疗冠心病合并脑梗死的临床疗效。方法:选取我院收治的冠心病合并脑梗死患者76例,随机分为两组,其中对照组36例,予改善循环、抗血小板聚集、扩冠、改善脑供血常规治疗,4周为1个疗程,治疗1个疗程;实验组40例,在常规治疗的基础上加用阿托伐他汀(立普妥)20mg,每日一次口服,苯磺酸氨氯地平(络活喜)5mg每日一次口服,4周为1个疗程。治疗结束后,对比治疗前后患者血清乳酸脱氢酶(LDH)、血清肌酸激酶(CK-MB)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及欧洲卒中量表(ESS)评分。结果:(1)治疗后两组患者心肌酶水平改善,且实验组LDH、CK-MB较对照组明显下降,差异有统计学意义(P<0.05);(2)治疗后两组患者血脂水平改善,且实验组TC、LDL-C较对照组明显下降,差异有统计学意义(P<0.05);实验组HDL-C较对照组明显上升,差异有统计学意义(P<0.05);(3)治疗后两组患者神经功能改善,且实验组ESS评分较对照组明显上升,差异有统计学意义(P<0.05)。结论:阿托伐他汀联合苯磺酸氨氯地平能够从根本上治疗冠心病合并脑梗死,确实具有良好的临床疗效,值得临床推广。Objective：To study the clinical effects of atorvastatin and amlodipine benzene in treatment of coronary heart disease complicated with cerebral infarction.Methods：A total of 76 patients with coronary heart disease complicated with cerebral infarction in our hospital were selected,and were randomly divided into two groups.36 cases in the control group received blood circulation,anti platelet aggregation,crown expansion,cerebral blood routine treatment for 4weeks;while 40 cases in experimental group had atorvastatin（Lipitor）20mg,once a day,oral,amlodipine besylate（Norvasc）5mg once a day orally for 4weeks.After treatment,serum lactate dehydrogenase（LDH）,serum creatine kinase（CK-MB）,cholesterol（TC）,low density lipoprotein（LDL-C）,high density lipoprotein（HDL-C）and the European Stroke Scale（ESS）score were detected and compared.Results：In the two groups myocardial enzyme levels were improved after treatment.LDH,CK-MB of experimental group were decreased significantly compared with the control group（P〈 0.05）.Serum lipid levels were improved in two groups after the treatment,TC,LDL-C of experimental group were decreased significantly compared with the control group（P〈 0.05）.HDL-C of experimental group was increased significantly（P〈 0.05）.Neural function was improved after treatment,and ESS score was increased significantly（P〈 0.05）.The differences in all indexes were significant between two groups（P〈 0.05）.Conclusions：Atorvastatin and amlodipine besylate is effective in treatment of coronary heart disease complicated with cerebral infarction,and is worthy the clinical promotion.

关 键 词：冠心病 脑梗死 阿托伐他汀 苯磺酸氨氯地平 

分 类 号：R541.4[医药卫生—心血管疾病]