2008-2011年云南省男男性行为人群HIV新发感染率调查  

HIV incidence in MSM in Yunnan, 2008-2011

作　　者：杨莉[1] 杨朝军[1] 陈会超[1] 马艳玲[1] 梅静远[1] 苏莹珍[1] 施玉华[1] 陈敏[1] 蒋岩[2] 贾曼红[1] 

机构地区：[1]云南省疾病预防控制中心,云南昆明650022 [2]中国疾病预防控制中心性病艾滋病预防控制中心国家艾滋病参比实验室,北京102206

出　　处：《现代预防医学》2015年第1期137-139,156,共4页Modern Preventive Medicine

基　　金：国家"十一五重大专项"艾滋病和病毒性肝炎等重大传染病防治"我国艾滋病流行规律;疫情评估和预测方法研究"(2008ZX10001-003);国家"十一五重大专项"云南省防治艾滋病规模化现场流行病学和干预研究项目(2009zx10004-902-4-018)

摘　　要：目的在男男性行为人群(MSM)中开展BED-CEIA HIV-1新发感染检测,以估算HIV新发感染率,了解流行趋势。方法对2008-2011年男男性行为人群艾滋病哨点监测中发现的HIV-1感染者进行BED-CEIA检测,估算经灵敏度-特异性校正后该人群的HIV-1年新发感染率,了解其变化趋势。同时设置静脉吸毒人群为对照组,观察该两类人群HIV-1新发感染率水平。结果研究对象共计24 880例。研究组MSM人群3 368例,检出HIV-1阳性300人(含既往阳性26人),完成BED-CEIA检测272人,判为新发感染112人。对照组注射吸毒(IDU)人群21 512例,检出HIV-1阳性3 794例,完成BED-CEIA检测1 791例,判为新发感染190例。2008-2011年MSM人群HIV-1感染率8.91%,低于同期IDU人群的17.6%,而HIV-1新发感染率为7.02%却显著高于同期IDU人群的0.97%。MSM人群2008-2011年HIV-1年新发感染率未出现明显的上升或下降趋势。结论 MSM人群HIV-1新发感染率四年来一直处于较高水平,需重点关注该类人群的艾滋病综合防治。Objective To estimate HIV incidence and epidemic trend with BED-CEIA test in men who have sex with men （MSM）. Method Samples from MSM sentinels were tested with BED-CEIA （BED-capture enzyme immunoassay） from 2008 to 2011. HIV-1 incidence rate was estimated after the sensitivity and specificity adjustment, and a comparison of incidence was made with a reference group of intravenous drug users （IDU）. Results A total of 24880 subjects were studied. There were 3368 MSM in the study group and 300 were diagnosed with HIV-1 infection including 26 previously diagnosed cases. 272 MSM were tested with BED-CEIA and 112 were confirmed with newly HIV-1 infections. In the reference group of 21512 IDUs, 3794 were diagnosed with HIV-1 infection and 190 were confirmed with newly HIV-1 infections by BED-CEIA test of 1791 subjects. The HIV-1 infection rate among MSM is 8.91% from 2008 to 2011, which is lower than that among IDUs （17.6%）. But the HIV-1 incident rate among MSM （7.02%） is higher than that of IDUs （0.97%）. The trend of HIV-1 incident rates of MSM from 2008 to 2011 does not show a noticeable variation. Conclusion HIV-1 incidence in MSM has been at a high level for the four years and corresponding comprehensive interference is required.

关 键 词：HIV-1 BED—CEIA检测 新发感染率 男男性行为人群 

分 类 号：R195.4[医药卫生—卫生统计学]