血清超敏C反应蛋白、转铁蛋白、补体C3和C4在儿童全身炎性反应综合征中的临床价值  

Clinical value of serum hypersensitive C-reactive protein, transferrin, complement C3 and C4 in children with systemic inflammatory response syndrome

作　　者：李梅爱[1] 曾华[2] 谭晓明[1] 刘海英[1] 黄钰君[1] 邝婉仪 黄映红[1] 

机构地区：[1]广州医科大学附属广州市妇女儿童医疗中心检验部,510120 [2]中山大学孙逸仙纪念医院检验科

出　　处：《中华生物医学工程杂志》2014年第3期235-238,共4页Chinese Journal of Biomedical Engineering

摘　　要：目的 探讨全身炎性反应综合征（SIRS）患儿血清超敏C反应蛋白（hs-CRP）、转铁蛋白（TRf）和补体C3、C4水平的变化及意义.方法 2012年7月至2013年6月本院PICU、NICU和急诊综合病区符合SIRS诊断的患儿93例（SIRS组）,对照组为年龄、性别与患儿相匹配的健康体检儿童65例,测定两组儿童血清中hs-CRP、TRf、补体C3和C4的水平.对93例患儿进行SIRS评分,根据评分分成A组（SIRS 2分）37例、B组（SIRS 3分）32例、C组（SIRS 4分）24例,比较3组血清中hs-CRP、TRf、补体C3和C4的水平并统计病死率,与SIRS评分进行相关分析.结果 SIRS组患儿血清hs-CRP水平高于对照组[（33.85±17.76）mg/L比（2.34±1.54） mg/L,P＜0.05].SIRS组血清TRf、补体C3和C4的水平均低于对照组[血清TRf：（1.26±0.48）g/L比（2.81±0.57）g/L,补体C3：（0.48±0.19）g/L比（1.14±0.21）g/L,补体C4：（0.19±0.09）g/L比（0.39±0.10）g/L,均P＜0.05].SIRS患儿血清hs-CRP水平随SIRS评分升高而升高,呈正相关（r=0.863,P＜0.05）,血清TRf、补体C3和C4的水平则随SIRS评分的升高而降低,呈负相关（r=-0.834、-0.715、-0.691,均P＜0.05）.病死率也随SIRS评分的升高而逐渐升高,呈正相关（r=1.00,P＜0.05）.结论 血清中hs-CRP、TRf、补体C3和C4的水平对评估SIRS患儿的病情和预后有重要意义.Objective To study the change and significance of serum hypersensitive C-reactive protein （hs-CRP）,transferrin （TRf）,complement C3 and C4 in children with systemic inflammatory response syndrome （SIRS）.Methods From July 2012 to June 2013,93 children with SIRS （SIRS group） in PICU,NICU and comprehensive department of emergency in our hospital were selected.The normal control group consisted of 65 healthy children who matched with study subjects for age and gender.The levels of hs-CRP,TRf,C3 and C4 in the serum of two groups were tested.The 93 patients were categorized into three groups according to SIRS score,including 37 cases of group A （SIRS score=2）,32 cases of groupB （SIRS score=3） and 24 cases of group C （SIRS score=4）.The levels of serum hs-CRP,TRf,complement C3 and C4 were compared with each other in three groups,and the correlation of these parameters with SIRS score was examined.And the fatality rates were stastically analyzed.Results The level of serum hs-CRP in SIRS group was higher than that of control group [（33.85±17.76）mg/L vs （2.34±1.54）mg/L,P＜0.05].The levels of serum TRf,complement C3 and C4 in SIRS group were lower than those in control group [serum TRf：（1.26±0.48） g/L vs （2.81 ±0.57） g/L; complement C3：（0.48±0.19） g/L vs （1.14±0.21） g/L; complement C4：（0.19±0.09）g/L vs （0.39±0.10）g/L,P＜0.05].The level of serum hs-CRP in SIRS children increased along with SIRS score increased,which presented positive correlation （r=0.863,P＜0.01）.And the levels of serum TRf,complement C3 and C4 decreased along with the SIRS score increased,which presented negative correlation （r=-0.834,-0.715,-0.691,all P＜0.05）.Also,the fatality rate increased gradually when the SIRS score increased,which presented positive correlation （r=1.00,P＜0.05）.Conclusion Levels of serum hs-CRP,TRf,complement C3 and C4 are significant to evaluate the condition and prognosis of children with SIRS.

关 键 词：全身炎性反应综合征 超敏C反应蛋白 转铁蛋白 补体C3 补体C4 儿童 

分 类 号：R720.597[医药卫生—急诊医学]