增龄引起心房离子通道重构与房颤的关系  

Association between atrial fibrillation and atrial ion channels remodeling induced by aging

作　　者：王璐珍[1] 欧贤红[1] 曾晓荣[1] 

机构地区：[1]泸州医学院心血管医学研究所医学电生理实验室,泸州646000

出　　处：《重庆医科大学学报》2014年第10期1351-1354,共4页Journal of Chongqing Medical University

基　　金：国家自然科学基金资助项目(编号:30870903);四川省科技支撑计划资助项目(编号:2011FZ0106);四川省卫生厅资助项目(编号:130263);泸州医学院自然科学基金重点资助项目

摘　　要：心房颤动(atrial fibrillation,AF),简称房颤,是临床上最为常见的快速性心律失常之一,尤其多见于老年人。年龄一直被认为是AF发生的重要危险因素之一。大量研究发现,心房重构(atrial remodeling,AR)是增龄性AF得以发生和维持的重要因素,心房肌细胞相关离子通道电流的变化及其通道蛋白、基因表达的变化在心房电重构(atrial electrial remodeling,AER)中起重要作用。本文就增龄引起心房离子通道重构与AF的关系予以综述。Atrial fibrillation（AF） is one of the most common clinical tachyarrhythmia,which is seen most frequently in the elderly. Ag- ing is regarded as an important risk factor for AF. A lot of researchers find that atrial remodeling plays an important role in occurrence and maintenance of the age-related AF. The changes of ion channel currents and its channel protein or gene expression in atrial my- ocytes are related to occurrence of atrial remodeling. This paper made a review on the recent studies of the relationship between AF and the changes which leaded by aging in atrial remodeling and ion channels.

关 键 词：心房颤动 增龄 心房重构 离子通道 

分 类 号：R541.7[医药卫生—心血管疾病]