酒精肝造模过程中的酒质对体重变化的影响  

Effects of alcohol quality on mouse weight in alcoholic liver model

作　　者：王晓琳[1] 陈小兰[1] 胡先福[1] 南清振[1] 陈楚弟[1] 

机构地区：[1]南方医科大学南方医院消化内科,510515

出　　处：《现代消化及介入诊疗》2014年第5期300-303,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：国家自然科学基金(81170743);广东省人才引进启动基金(2010111501)

摘　　要：目的研究小鼠酒精性肝病造模过程中的不同酒质的作用。方法小鼠慢性喂养工业酒精2个月,或喂养食用酒A或食用酒B 40 d。检查小鼠空腹体重及病理组织学的变化。结果工业酒精慢性喂养2个月后,体重比对照组显著下降,说明工业酒精作为慢性酒精喂养模型的不适用问题。于是,我们进一步使用食用酒A,食用酒B分别慢性酒精喂养40 d后,体重仍然下降约20%。于是比较两种使用食用酒间隔5 d或10 d的慢性喂养85 d情况下(含酒精为40 d),食用酒B的体重降低有明显改善。三种酒喂养情况下,组织学均未见显著性差异。结论从体重的变化看,酒精质量对此模型具有重要的意义。Objective To study the effects of alcohol quality on mouse weight in alcoholic liver model. Method Mice were fed with industrial alcohol for 2 months, or two kinds of liquor for 45 days. Mice weight change and liver tissue pathology were examined. Results After 2-month industrial alcohol feeding, body weight of the mice was decreased by 97.4%compared with the control mice, indicating that the industrial al-cohol was not suitable for the study. Mice were further fed with two kinds of liquor with different quality for 45 days. The body weight was decreased by 20.4%and 19.1%for poorer quality liquor and higher quality liquor respectively. We thus fed mice with two kinds of liquor in every 5 days or every 10 days for a total of 85 days. It was observed that the body weight was decreased much less in mice fed with higher quality liquor compared with the mice fed with poorer quality wine in both experimental designs. No change was observed in liver tis-sue pathology between the mice fed with different alcohols. Conclusion Liquor quality is important for the chronic alcoholic study.

关 键 词：小鼠 酒精模型 体重增长 肝脏病理 

分 类 号：R544.1[医药卫生—心血管疾病]