体外循环冠脉搭桥手术后认知功能障碍的预测因素研究  

Analysis of Predictors of Postoperative Cognitive Deficits of Coronary Artery Bypasses Surgery under Extracorporeal Circulation

作　　者：张跃军[1] 李航[1] 

机构地区：[1]温州医科大学附属东阳医院麻醉科,322100

出　　处：《医学研究杂志》2014年第11期119-121,共3页Journal of Medical Research

摘　　要：目的研究分析体外循环冠脉搭桥手术术后认知功能障碍(POCD)的预测因素。方法对448位体外循环冠脉搭桥手术患者手术前后行的认知功能测验进行比较,得出POCD发生率,并通过逻辑回归分析方法确定POCD的预测因素。结果59%的患者发生POCD,与POCD发生明显相关的预测因素包括术中体温异常、左心室功能受损、血清肌酐含量上升、肌酐清除率下降、气管插管时间延长。而高龄、伴随劲动脉疾病以及体外循环与术后POCD的发生无明显相关性。结论患者术前存在血清肌酐含量上升和左心室功能下降是体外循环冠脉搭桥手术POCD发生的高危因素。Objective To analysis the predictors of postoperative cognitive deficits occur in patients undergoing on-pump coronary artery bypass surgery.Methods Preoperative and postoperative cognitive testing were performed in 448 patients undergoing coronary artery bypass graft to evaluate the occurrence and predictors of POCD.Results 59％ of patients occurred POCDs,while the high relation predictors were intraoperative normothermia,low left ventricular function,high serum creatinine,low creatinine clearance and prolonged intubation time.Aged,carotid disease and cardiopulmonary bypass time were not associated with increased POCDs.Conclusion Patients with elevated pre-operative creatinine and low LV function carry a higher risk of POCDs.

关 键 词：体外循环 冠状动脉旁路 术后认知功能障碍 

分 类 号：R619[医药卫生—外科学]