微波辅助照射治疗结核性胸膜炎的疗效观察  

Observation on Clinical Efficacy of Microwave Irradiation for the Treatment of Tuberculous Pleurisy

作　　者：齐海亮[1] 章志华[1] 郑立恒[1] 苏宏伟[1] 杜秀然[1] 王鹏[1] 李明珠[1] 徐伟乐[1] 

机构地区：[1]河北省胸科医院,河北石家庄050041

出　　处：《医学临床研究》2014年第10期1876-1879,共4页Journal of Clinical Research

基　　金：河北省医学科学研究重点课题（NOZL20140131）

摘　　要：【目的】探讨微波辅助照射治疗结核性胸膜炎的疗效。【方法】选取结核性胸膜炎患者97例，根据治疗方法分为治疗组和对照组，两组均给予相同的抗结核方案，即3HRZE／6HR，并行胸腔置管，注射无菌的利福平针剂；治疗组在此基础上加用微波局部照射治疗，每次照射15min，每日2次，治疗4周；比较两组胸膜厚度、用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、肺总量（TLC）等指标。【结果】治疗组、对照组胸水分别在（12．4±3．1）d、（18．5±4．2）d消失；治疗组胸膜厚度、FVC（％）、FEV1（％）、TLC（％）分别为（1．21±0．35）mm、（87．5±7．30）、（87．4±6．4）、（88．3±3．6），与对照组（1．96±0．56）mm、（79．3±7．4）、（78．3±5．6）、（79．3±4．2）比较均有统计学意义（P〈0．05）；而两组不良反应和复发率比较无统计学差异（P〉0．05）。【结论】在规范抗结核基础上，采用微波辅助局部照射治疗结核性胸膜炎操作方便、疗效显著，值得临床推广应用。[Objective] To observe the clinical effect of adjuvant microwave irradiation for the treatment of tuberculous pleurisy. [Methods] Totally 97 patients with tuberculous pleurisy were chosen. According the treatment methods, all patients were divided into treatment group and control group. Both groups were given the same anti-tuberculosis program 3HRZE/6HR together with intubation in thoracic cavity and injection of sterile rifampicin. The treatment group was additionally given local irradiation of microwave. Each irradiation time was 15min, and the irradiation lasted twice a day for 4 weeks. Pleura thickness, forced vital capacity （FVC）, forced expiratory volume in one second（FEV1） and total lung capacity（TLC） were compared between 2 groups. [Results] Pleural effusion in both groups disappeared at （12.4±3.1） d.（18. 5±4.2）d. Pleural thickness, FVC（%）, FEVI（%） andTLC（%） in treatment group were （1.21±0.35）mm, （87.5±7.30）, （87.4±6.4） and （88. 3 ±3. 6） respectively, and there were significant differences between the treatment group and control group [（1.96±0.56）mm, （79.3±7.4）, （78. 3±5.6） and （79.3±4.2）]（ P 〈0.05）. There was no significant difference in adverse reaction and recurrence between two groups（ P 〉0.05）. [Conclusion]Local irradiation with microwave is an effective treatment of tuberculous pleurisy and worthy of clinical promotion.

关 键 词：利福平/投药和剂量 结核 胸膜/药物疗法 微波 治疗结果 

分 类 号：R521.7[医药卫生—内科学]