成纤维细胞生长因子-21与2型糖尿病大血管病变的相关性  

Study on the Relationship Between Fibroblast Growth Factor-21 and Diabetic Macroangiopathy

作　　者：顾蕾[1] 宋晓敏[1] 周尊海[1] 蔡晓莺[1] 朱文[1] 张玄娥[1] 

机构地区：[1]上海市杨浦区中心医院内分泌科,上海200090

出　　处：《医学临床研究》2014年第10期1906-1908,共3页Journal of Clinical Research

摘　　要：【目的】探讨2型糖尿病（T2DM ）合并大血管病变患者血浆成纤维细胞生长因子‐21（FGF‐21）水平变化以及观察短期胰岛素强化治疗对FGF‐21水平的影响。【方法】采用酶联免疫法测定30例健康对照组和34例初诊T2DM患者（T2DM组）、28例T2DM合并大血管病变患者（合并大血管病变组）血浆FGF‐21水平以及胰岛素强化治疗前后的变化，分析血浆FGF‐21水平与体质量指数（BMI）、腰臀比（WHR）、血脂、血糖、空腹血浆胰岛素（FINS）和糖化血红蛋白（HbA1C）等水平的关系。【结果】T2DM 合并大血管病变患者FGF‐21水平明显升高，空腹血浆FGF‐21水平与FPG、HbA1C呈明显正相关，WHR、舒张压、HbA1C是影响血浆FGF‐21水平的独立相关因素。经胰岛素强化治疗后血浆FGF‐21水平较治疗前明显下降。【结论】血浆FGF‐21可能参与了 T2DM 及其大血管病变的发生和发展，胰岛素强化治疗可明显降低T2DM患者血浆FGF‐21水平。[Objective]To explore the change of plasma fibroblast growth factor 21（FGF‐21） in type 2 diabetes melli‐tus（T2DM） patients with macroangiopathy ,and to observe the effect of short‐term intensive insulin therapy on FGF‐21 level .[Methods]Enzyme linked immunosorbent assay （ELISA） was used to detect plasma FGF‐21 in 30 healthy controls （control group） ,34 patients with newly diagnosed T2DM（T2DM group） and 28 T2DM patients with macroangiopathy （diabetic macroangiopathy group ） .The change of FGF‐21 before and after intensive insulin therapy was observed .The relationship of plasma FGF‐21 with body mass index（BMI） ,waist/hip ratio（WHR） ,blood lipids ,plasma glucose ,fast‐ing plasma insulin（FIN2） and glycosylated hemoglobin（HbA1C） was analyzed .[Results] Plasma level of FGF‐21 in T2DM patients with macroangiopathy was increased obviously .The fasting plasma FGF‐21 level was positively correlated with FPG and HbA1C .The WHR ,diastolic pressure and HbA1C were the independent factors influencing plasma level of FGF‐21 .Compared with before treatment ,plasma level of FGF‐21 after intensive insulin therapy was reduced obvious‐ly .[Conclusion]Plasma FGF‐21 may participate in the pathogenesis and development of T 2DM and diabetic macroangiop‐athy .Short‐term intensive insulin therapy can obviously decrease plasma FGF‐21 level in T2DM patients .

关 键 词：成纤维细胞生长因子/血液 糖尿病 2型 糖尿病血管病变 

分 类 号：R587.1[医药卫生—内分泌]