消渴康颗粒联合盐酸吡咯列酮片治疗2型糖尿病阴虚热盛型临床观察  

Clinical Observation of Xiaokekang Combined with Pioglitazone in Treating Yin Deficiency and Excessive Heat Type 2 Diabetic Patients

作　　者：张磊[1] 洪兵[1] 

机构地区：[1]淮安市中医院内分泌科,江苏淮安223001

出　　处：《辽宁中医药大学学报》2014年第12期117-119,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：江苏省中医药管理局课题资助项目(LZ13175)

摘　　要：目的:观察消渴康颗粒联合盐酸吡咯列酮片对2型糖尿病阴虚热盛型患者糖脂代谢的影响。方法:74例2型糖尿病阴虚热盛型患者按随机数字表法分为两组,每组37例。两组均行糖尿病生活方式干预。对照组用盐酸吡咯列酮片30 mg,每日1次口服;观察组在对照组基础上加用消渴康颗粒,1剂,每日3次温服。治疗12周。两组患者均于治疗前后检测空服血糖(FBG)、糖化血红蛋白(Hb A1C)、餐后2 h血糖(2 h PG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并进行疗效评定。结果:临床疗效总有效率观察组为97.30%(36/37),对照组为62.16%(23/37),观察组优于对照组(P<0.05)。症状积分及FBG、2 h PG、TC、TG、HDL-C、LDL-C水平治疗前后及治疗后两组比较差异均有统计学意义(P<0.05)。结论:消渴康颗粒与盐酸吡咯列酮片合用能有效降低2型糖尿病阴虚热盛型患者血糖、血脂水平,可明显提高疗效,改善糖脂代谢。Objective ： To observe the effect of Xiaokekang combined with pioglitazone on glucose and lipid metabolism of Yin deficiency and excessive heat type 2 diabetic patients （ T2DM ）. Methods ： Totally 74 Yin deficiency and excessive heat T2DM patients were randomly divided into two groups （ each contained 37 cases ）, and given the diabetes lifestyle intervention. Control group additionally took 30mg pioglitazone daily. And treatment group, besides taking 30mg pioglitazone, was given Xiaokekang, one dose and three times per day warmly. After 12 weeks, FBG, HbA1C, TC, TG, HDL-C, LDL-C,2 hPG of the two groups were determined, and the therapeutic effect was evaluated. Results ： The total effective rate in the treatment group was 97.30%, and 83.78% in control group （ P〈0.01 ）. The difference in symptom score, FBG, 2 hPG, TC, TG, HDL-C and LDL-C between the two groups were significant, so as that before and after treatment of both groups （ P〈0.05 ） . Conclusion ： Xiaokekang combined with pioglitazone can effectively lower the levels of blood glucose and blood lipid in Yin deficiency and excessive heat T2DM patients, enhance the therapeutic effect and improve the metabolism of glucose and lipid.

关 键 词：糖尿病 阴虚热盛 糖脂代谢 消渴康颗粒 吡咯列酮 

分 类 号：R587.1[医药卫生—内分泌]