不同方法治疗轻度肾功能不全并发心绞痛患者的临床观察  

Clinical observation of different methods in the treatment of patients with mild renal dysfunction complicated with angina pectoris

作　　者：杨新滨 王明毅[1] 张宇静[1] 关红[1] 徐健[1] 

机构地区：[1]沈阳市第一人民医院心血管内科,沈阳110041

出　　处：《中国当代医药》2014年第34期44-46,共3页China Modern Medicine

摘　　要：目的 观察单纯药物与PCI治疗轻度肾功能不全合并心绞痛患者的效果及安全性.方法 回顾性分析2009年1月～2014年6月入院的轻度肾功能不全并发心绞痛患者,单纯药物治疗66例（药物组）,PCI治疗68例（PCI组）,PCI组检测入院时、术后及出院时的血肌酐水平,药物组检测入院时及出院时血肌酐水平及两组终点事件发生率.结果 PCI组术后、出院时血肌酐水平较基线相比差异无统计学意义（P＞0.5）;两组基线、出院时血肌酐水平比较差异均无统计学意义（P＞0.5）.药物组复合终点发生率（16.67％）高于PCI组（4.41％）,差异有统计学意义（P=0.04）.结论 PCI治疗与药物保守治疗相比,临床症状缓解率高,虽有造影剂肾病发生,但急性肾衰及需透析风险不高,较药物治疗对轻度肾功不全的患者更有益.Objective To observe the efficacy and the safety of the medication only and percutaneous coronary intervention （PCI）in the treatment of patients with mild renal dysfunction complicated with angina pectoris. Methods The clinical data of angina patients with mild renal dysfunction complicated with angina pectoris from January 2009 to June 2014 in our hospital were retrospectively analyzed.Medication treatment was used in medication group of 66 patients,PCI was used in PCI group of 68 cases.Serum creatinine levels at admission,postoperative and discharge in PCI group were detected,serum creatinine levels at admission and discharge in medication group were detected.Incidence rate of endpoint event in two groups were compared. Results Serum creatinine levels at postoperative and discharge in PCI group compared with at admission respectively,with no statistical difference （P〉0.5）.Serum creatinine levels at admission and discharge in two groups was compared respectively,with no statistical difference （P〉0.5）.The incidence rate of the composite endpoint in medication group （16.67%）was higher than that in PCI group （4.41%）（P=0.04）. Conclusion Compared with medication,clinical symptom remission rate of PCI is high.Although it has contrast-induced nephropathy occurs,but the risk of acute renal failure and need dialysis is not high.PCI compared with drug therapy in patients with mild renal dysfunction is better.

关 键 词：轻度肾功不全 心绞痛 冠脉介入 造影剂肾病 

分 类 号：R692[医药卫生—泌尿科学]