复方紫苏制剂抗模拟空间运动病的有效部位筛选  

Screening Effective Chemical Constituents of Compound Preparation of Perilla Nankinensis for Anti-simulated Space Motion Sickness

作　　者：赵姣[1,2] 卢卫红[1,2] 李勇枝[1,3] 陈家晟 杨雨茗 

机构地区：[1]哈尔滨工业大学极端环境营养与防护研究所,黑龙江哈尔滨150090 [2]哈尔滨工业大学食品科学与工程学院,黑龙江哈尔滨150090 [3]中国航天员科研训练中心,北京100094

出　　处：《中医药信息》2014年第6期1-4,共4页Information on Traditional Chinese Medicine

基　　金：哈尔滨市优秀学科带头人项目(No.RC2013XK020010);985理工医交叉研究项目(No.HIT.IBRSEM.201336);颠覆性技术培育项目(2013)

摘　　要：目的:筛选复方紫苏制剂抗模拟空间运动病的有效化学部位。方法:将复方紫苏制剂分成水提物、正丁醇萃取物及乙醇提取物三个化学部位,通过对小鼠旋转晕刺激的方法建立模拟空间运动病模型,观察各给药组小鼠异食高岭土及进食量的变化。结果:正丁醇萃取物能显著降低小鼠晕刺激后高岭土的摄入量,并改善小鼠晕刺激后食欲降低的现象,其抗运动病效果优于其他化学部位及阳性对照(茶苯海明)。结论:正丁醇萃取物为复方紫苏制剂抗运动病的有效化学部位。Objective：To screen the effective chemical constituents of compound preparation of perilla nankinensis for anti-simulated space motion sickness.Methods：Divide compound preparation of perilla nankinensis into three chemical constituents：aqueous extract,n-butanol solvent extract and ethanol extract.Motion sickness of mice was induced by rotatory stimulation.The comsumption of kaolin and food intake was caculated as the index of motion sickness.Results：The n-butanol solvent extract could inhibit the consumption of Kaolin and reduce the appetite drops significantly after motion sickness of mice was induced ; the effect on anti-motion sickness was better than other chemical constituents and the positive control （dimenhydrinate）.Conclusion：The n-butanol solvent extract is the most effective chemical constituent of compound preparation of perilla nankinensis for anti-simulated space motion sickness.

关 键 词：复方紫苏 空间运动病 有效部位 高岭土 进食量 正丁醇萃取物 

分 类 号：R285.5[医药卫生—中药学]