乙酰水杨酸催化合成条件的研究  

Study on Catalytic Synthesis Conditions of Acetyl Salicylic Acid

作　　者：黄飞[1] 屈飞强 任晓琼[1] 姚兵[1] 孙金余[1] 王溪溪[1] 

机构地区：[1]黄山学院化学化工学院,安徽黄山245041

出　　处：《长江大学学报（自科版）（上旬）》2014年第10期20-23,3,共4页JOURNAL OF YANGTZE UNIVERSITY (NATURAL SCIENCE EDITION) SCI ＆ ENG

基　　金：国家级大学生创新创业训练计划项目(201410375003);安徽省大学生创新创业训练计划项目(AH201310375027);黄山学院自然科学研究项目(2012xkj006)

摘　　要：以水杨酸和乙酸酐为原料,经O-酰化反应合成了乙酰水杨酸,并分析了催化剂种类、水杨酸与乙酸酐的物质的量比、反应时间和反应温度对催化合成的影响。结果表明,合成乙酰水杨酸的最优条件为:草酸作为催化剂,水杨酸与乙酸酐的物质的量比为1∶3,反应温度为70℃,反应时间为60min,乙酰水杨酸产率可达88.2%。该方法操作简单,经济环保,产品质量好,适用于工业化生产。Acetyl salicylic acid is synthesized through O-acylating reaction from salicylic acid and acetic anhydride.The catalysts,the molar ratio of salicylic acid and acetic anhydride,reaction time and reaction temperature are explored.The results show that optimal conditions of acetyl salicylic acid synthesis include that when oxalic acid is as catalyst,the molar ratio of salicylic acid and acetic anhydride is 1∶3,reaction temperature is 70℃,reaction time is 60 minutes,the acetyl salicylic acid yield is up to 88.2%.The method has the advantage of simplification,economy,no pollution and good quality of product,it is suitable for industrial production.

关 键 词：水杨酸 乙酸酐 乙酰水杨酸 催化合成 

分 类 号：O625[理学—有机化学]