铁积聚在术后认知功能障碍中的作用  

The role of iron accumulation in postoperative cognitive dysfunction

作　　者：舒瑞辰 张麟临 王超[1] 王海云[1] 王国林[1] 

机构地区：[1]天津医科大学总医院麻醉科,天津市麻醉学研究所,300052

出　　处：《国际麻醉学与复苏杂志》2014年第12期1144-1147,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（30972847,81371245）;天津市科技支撑项目（12ZCZDSY03000）

摘　　要：背景术后认知功能障碍（postoperative cognitive dysfunction，POCD）是麻醉手术后常见的神经系统并发症，尤其在老年人多见。脑内铁积聚是一些神经退行性病变的起始因素，通过诱发氧化应激损伤，引起神经元变性坏死。目的探讨铁积聚在POCD中的作用。内容描述脑内铁分布，铁代谢蛋白功能，铁积聚与神经退行性变的关系以及其在POCD中的研究进展。趋向铁积聚可能是引发POCD的重要机制，铁鳌合剂的神经保护作用有望为POCD的治疗提供新思路。Background Postoperative cognitive dysfunction （POCD） is a common neurological complication after anesthesia and surgery, especially prevalent in the elderly. Iron accumulation in the brain is an initial cause of neurodegeneration, it gives rise to neuronal degeneration and necrosis by arousing oxidative stress. Objective This review aims to investigate the role of iron accumulation in POCD. Content The distribution of brain iron, iron metabolism protein function, the relationship of excessive iron levels in the brain and neurodegeneration, as well as the progress of iron accumulation in POCD are described in the article. Trend Iron accumulation may be an important mechanism of POCD, the neuroprotection of iron chelator is expected to provide new target for the management of POCD.

关 键 词：铁积聚 神经退行性病变 术后认知功能障碍 

分 类 号：R614[医药卫生—麻醉学]