金天格胶囊对骨质疏松性骨折大鼠BGP、TRACP表达的影响  

Effect of Jintiange capsules on the expressions of BGP and TRACP in rats with osteoporotic fractures

作　　者：赵玉玺[1] 张彬[1] 湛梅圣[1] 王万垠[1] 杨建强[1] 胡耀芬 孙海萍[1] 吴璇[2] 

机构地区：[1]湖北省枣阳市第一人民医院骨科,枣阳441200 [2]湖北省枣阳市第一人民医院五官科,枣阳441200

出　　处：《中国骨质疏松杂志》2014年第11期1302-1305,共4页Chinese Journal of Osteoporosis

摘　　要：目的研究一种新的国家一类中药金天格胶囊对骨质疏松性骨折大鼠骨代谢因子的影响。方法建立绝经后骨质疏松性骨折大鼠模型,给予雌激素及不同浓度的金天格胶囊灌胃,并于灌胃治疗5周后,采用酶联免疫吸附法(ELISA)测定骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP)的表达。结果模型组大鼠的BGP、TRACP的阳性表达明显升高(P<0.05);中、低剂量的金天格胶囊可使大鼠的BGP、TRACP的阳性表达明显下降(P<0.05),而高剂量金天格胶囊的干预效果不显著(P>0.05)。结论金天格胶囊对PMOP大鼠具有降低BGP、TRACP的分泌,促进骨折愈合的作用。Objective To study the effect of a new class I Chinese state medicine, Jintiange capsules, on the rat bone metabolism factors in osteoporotic fractures.Methods The rat postmenopausal osteoporotic fracture model was established.Different concentrations of Jintiange capsules or estrogen were administered by gastric perfusion.After 5 weeks of the treatment, osteocalcin （ BGP） and tartrate resistant acid phosphatase （ TRACP） were determined using ELISA.Results The positive expression of BGP and TRACP in rats of model group increased significantly （P〈0.05）.Low and middle doses of Jintiange capsules significantly decreased the positive expression of BGP and TRACP （P〈0.05）.No significant intervention effect was observed with high dose of Jintiange capsules （P〉0.05）.Conclusion Jintiange capsules can reduce the secretion of BGP and TRACP in PMOP rats, and promote the healing of the fractures.

关 键 词：骨质疏松 金天格胶囊 骨钙素 抗酒石酸酸性磷酸酶 

分 类 号：R68[医药卫生—骨科学]