老年骨质疏松症患者25羟维生素D_3水平的季节变化  

Seasonal variation of 25-hydroxyvitamin D level in patients with senile osteoporosis

作　　者：姜礼红[1] 王秋军[1] 周萍[1] 朱秀英[1] 王丽平[1] 陶天遵[1] 范鹰[1] 孟佳[1] 

机构地区：[1]哈尔滨医科大学附属第二医院老年病科,哈尔滨150086

出　　处：《中国骨质疏松杂志》2014年第11期1357-1359,共3页Chinese Journal of Osteoporosis

摘　　要：目的本文通过测定我院就诊的老年骨质疏松症患者体内25羟维生素D3水平,分析目前维生素D治疗状况并评价其与季节的关系。方法 50例老年骨质疏松症患者(均符合1994年WHO关于骨质疏松症的诊断标准),其中男性28名,平均年龄75.6±1.5岁,女性22名,平均年龄69.3±2.6岁,用放射免疫分析法测定冬夏两季25(OH)D3、钙、磷、碱性磷酸酶、甲状旁腺素含量。结果所有患者夏季25(OH)D3水平明显高于冬季(男性高42.5%,女性高54.6%,P<0.05)。维生素D缺乏情况:女性夏季为13.64%,冬季为36.36%,男性夏季为7.14%,冬季35.71%,冬季维生素D缺乏明显高于夏季(P<0.05),男女两组钙、磷、碱性磷酸酶、甲状旁腺素含量均在正常范围。结论老年骨质疏松症患者在不同季节存在着不同程度的维生素D缺乏,冬季25(OH)D3水平更低。建议老年人科学合理应用维生素D,应该将定期监测25(OH)D3水平作为骨质疏松症治疗的常规实验室检查,并为临床合理应用维生素D提供科学的理论依据。Objective This study aims to analyze the current clinic treatment using vitamin D for osteoporosis and its relationship with season via measuring the 25-hydroxyvitamin D3 [25（OH）D3] level in senile patients with osteoporosis.Methods Fifty cases of senile osteoporosis were included in this study （in accordance with the WHO diagnostic criteria for osteoporosis, 1994）, in which 28 were males with mean age of 75.6 ＆#177;1.5 years, and 22 were females with mean age of 69.3 ＆#177;2.6 years. Radioimmunoassay was applied to determine the serum 25 （ OH ） D3 level in summer and winter, respectively.The content of calcium, phosphorus, alkaline phosphatase, and parathyroid hormone were also measured.Results Among all of the patients, the serum 25（OH）D3 levels in summer were significantly higher than those in winter （males：42.5%higher, females：54.6%higher, P〈0.05 ） .The vitamin D deficiency situation was 13.64% of women in summer and 36.36% in winter, 7.14% of men in summer and 35.71% in winter, respectively.Significantly high vitamin D deficiency happened in winter comparing with that in summer （ P 〈0.05 ） .The serum calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels were within the normal range in two groups.Conclusion There are different degrees of vitamin D deficiency in elderly patients with osteoporosis in different seasons.The serum 25（OH）D3 levels in winter were lower.It is recommended of scientific and rational application of vitamin D among the elderly.The serum 25（OH）D3 levels should be regularly monitored as routine laboratory test for osteoporosis treatment, which may provide theoretical basis for reasonable clinical application of vitamin D in the treatment of senile osteoporosis.

关 键 词：老年骨质疏松症 维生素D 季节 

分 类 号：R592[医药卫生—老年医学]