突发性聋患者血小板平均体积检测结果分析  

The Relationship of Mean Platelet Volume and Sudden Sensorineural Hearing Loss

作　　者：郑雪松[1] 后农生[1] 郝锐[2] 

机构地区：[1]北华大学附属医院耳鼻咽喉科,吉林132011 [2]北华大学附属医院感染科

出　　处：《听力学及言语疾病杂志》2014年第6期600-602,共3页Journal of Audiology and Speech Pathology

摘　　要：目的分析突发性聋患者血小板平均体积（mean platelet volume,MPV）变化,初步探讨突发性聋的可能病因。方法以40例（40耳）突发性聋患者为研究对象（突聋组）,其中轻度-中重度组（听力损失25~70dB）15例（耳）,重度-极重度组（听力损失≥71dB）25例（耳）,另选择30例健康成人为对照组,比较两组外周血中血小板计数（PLT）、血小板平均体积（MPV）、血小板分布宽度（PDW）的水平。结果突聋组血小板计数为212.0±47.9×109/L,对照组为237.8±46.2×109/L,突聋组低于对照组,差异有统计学意义（P〈0.05）;突聋组MPV为10.9±0.8fL,对照组为10.3±0.8fL,突聋组高于对照组,差异有统计学意义（P〈0.05）;突聋组PDW为12.9%±2.0%,对照组为12.0%±1.3%,突聋组高于对照组,差异有统计学意义（P〈0.05）。突聋组中轻度-中重度组MPV为11.0±1.1fL,重度-极重度组MPV为10.8±1.0fL,两组比较差异无统计学意义（P〉0.05）,两组MPV分别与对照组比较,差异均有统计学意义（P〈0.05）。结论 MPV是血栓性疾病发生的独立危险因素,突发性聋患者MPV升高可能与内听道血管缺血或血栓事件有关。Objective Our aim was to investigate the association between sudden sensorineural hearing loss （SSHL）and mean platelet volume （MPV）values,in order to evaluate the etiology of SSHL.Methods This study included 40 patients with SSHL in our ward between Jan.2012 and Jan.2014 and 30 age- and sex-matched healthy subjects were included as controls.The correlation among the levels of the number of platelets,mean plate-let volume（MPV）,platelet distribution width （PDW）was evaluated in the two groups.ResuIts The platelet count was significantly lower in the SSHL than the control group（212.0±47.9 versus 237.8±46.2 ＆#215;109/L）.MPV and PDW were significantly higher in SSHL（10.9±0.8 versus 10.3±0.8 fL;12.9%±2.0% versus 12.0%±1.3 %）. The SSHL patients were divided two subgroups：the mild-moderate subgroup （hearing loss 25~70 dB）and the se-vere subgroup（hearing loss≥70 dB）.The MPV values were insignificantly different between the two subgroups（11. 0±1.1 fL versus 10.8 ±1.0 fL）.Compared to the control group,the two subgroups had both significant differ-ences in MPV.ConcIusion High MPV values are a risk factor for thrombotic vascular diseases.Considering the in-creased MPV levels,SSHL appears to be characterized by ischaemic or thrombotic events.

关 键 词：血小板平均体积 突发性聋 血栓性疾病 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]