纳米羟基磷灰石/壳聚糖复合微球的原位仿生制备及表征  

In situ Biomimetic Fabrication and Characterization of Nano-hydroxyapatite/Chitosan Composite Microspheres

作　　者：李健[1] 韩志军[1] 魏延[1] 牛璐璐 刘宇[1] 路国运[2] 黄棣[1] 

机构地区：[1]太原理工大学力学学院-材料强度与结构冲击山西省重点实验室,太原030024 [2]太原理工大学应用力学与生物医学工程研究所,太原030024

出　　处：《无机材料学报》2014年第12期1327-1332,共6页Journal of Inorganic Materials

基　　金：国家自然科学基金(11372209,51203028);山西省青年科技基金(2013021014-2);山西省高等学校科技创新项目(2013111)~~

摘　　要：为解决纳米羟基磷灰石/壳聚糖(nHA/CS)复合微球中nHA团聚及分散不均的问题,本研究在油包水的乳液体系中,原位仿生制备了nHA/CS复合微球,并与共混法制备的nHA/CS复合微球进行了对比研究。利用扫描电镜(SEM)、X射线能谱(EDS)、X射线衍射(XRD)、红外(FTIR)和激光粒度仪等手段对不同微球的理化性能进行表征。结果表明:相比共混法,原位仿生制备的nHA/CS复合微球形态圆整均匀,分散性好,粒径分布较窄,平均粒径为8.62μm,nHA晶体均匀分布在微球内部及表面,并与CS基质以化学键结合。该复合微球有望用于骨组织工程及药物控制释放。To solve the problem that nano-hydroxyapatite （nHA） crystals aggregation and non-uniformly distribution in nano-hydroxyapatite/chitosan （CS） composite microspheres, nHA/CS microspheres were prepared through in situ biomimetic method in water-in-oil （W/O） emulsions. The physical and chemical properties of the composite micro- spheres were investigated by scanning electronic microscopy （SEM）, X-ray energy-dispersive spectroscope （EDS）, X-ray diffraction （XRD）, fourier transform infrared spectroscope （FTIR） and laser particle size analyzer. The results indicate that the composite microspheres are spherical with average size of 8.62μm and disperse uniformly. Moreover, the nHA crystals are dispersed uniformly within composite microspheres and bonded with CS matrix. The composite microspheres have great potential in bone tissue engineering and drug delivery system.

关 键 词：原位仿生 纳米羟基磷灰石 壳聚糖 复合微球 

分 类 号：TB33[一般工业技术—材料科学与工程]