5-脂氧合酶及其抑制剂  

5-Lipoxygenase and its Inhibitors

作　　者：黄凯[1] 蒋世云[1] 陈柳军[2] 

机构地区：[1]广西科技大学生物与化学工程学院,广西柳州545006 [2]广西柳州市疾病预防控制中心,广西柳州545006

出　　处：《中国生物化学与分子生物学报》2014年第12期1190-1196,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：广西自然科学基金项目(No.2013GXNSFAA019168)~~

摘　　要：5-脂氧合酶(5-lipoxygenase,5-LOX)是生物体内一种重要的双加氧酶.5-LOX是催化花生四烯酸(arachidonic acid,AA)生成白三烯类(leukotrienes,LTs)的关键酶.LTs是重要的炎症介质,并且在许多疾病中发挥着重要作用.近年来,很多学者致力于5-LOX的研究,从而为5-LOX抑制剂的研发提供理论依据.本文对5-LOX的分子结构、细胞内定位、表达与活性调控及其抑制剂的研究进展进行综述.The 5-lipoxygenase （5-LOX） is an important dioxygenase in organisms, which is the key enzyme catalyzing arachidonic acid into leukotrienes （LTs）. L Ts is a potent mediator of the inflammatory response and plays important roles in many diseases. 5 -LOX has a single polypeptide chain with a molecular mass of 75 - 80 kD and 673 amino acid residues in animals, which has a N -terminaljs-barrel domain and a larger catalytic domain containing a single atom of non-heme iron. The cell-type-specific localization of 5 -LOX is determined by the balance of nuclear localization signal （NLS） - and nuclear export signal （NES） -dependent mechanisms. In addition, only granulocyte, mast cells, dendritic cells and B lymphocytes can express 5-LOX. Also Ca^2＋ , ATP, FLAP and so on are required for 5-LOX activity. In the recent years, the research of 5-LOX focused on the development of 5-LOX inhibitors.

关 键 词：5-脂氧合酶 白三烯类 炎症 5-脂氧合酶抑制剂 

分 类 号：Q55[生物学—生物化学]