纵隔淋巴结与原发灶最大标准摄取值比值对非小细胞肺癌纵隔淋巴结转移的诊断价值  

Maximum standardized uptake value ratio of mediastinal lymph node to primary tumor in dignosis of mediastinal lymph node metastasis in patients with non-small cell lung cancer

作　　者：叶鹏飞[1] 韩星敏[1] 谢新立[1] 程兵[1] 牛晓博[1] 

机构地区：[1]郑州大学第一附属医院核医学科,河南郑州450052

出　　处：《中国医学影像技术》2014年第12期1839-1843,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨纵隔淋巴结与原发灶最大标准摄取值(SUVmax)比值(LN/T)对非小细胞肺癌(NSCLC)纵隔淋巴结转移的诊断价值。方法对103例NSCLC患者于术前行PET/CT检查,对图像进行视觉分析和半定量分析,分别测量原发灶及纵隔淋巴结的SUVmax,计算LN/T,以纵隔淋巴结术后病理结果为标准将纵隔淋巴结分为转移组和未转移组。采用独立样本t检验比较转移组和未转移组淋巴结LN/T的差异;采用ROC曲线确定LN/T诊断纵隔淋巴结转移的最佳界值。结果 103例NSCLC患者中共检出346枚淋巴结,转移组淋巴结85枚,未转移组261枚。转移组淋巴结LN/T(0.55±0.39)高于未转移组(0.20±0.10),二者差异有统计学意义(P<0.001);以LN/T≥0.25为界值,判断淋巴结转移的灵敏度、特异度和准确率分别为72.94%、79.31%、77.75%。结论 LN/T可以作为一项判断NSCLC患者纵隔淋巴结转移的半定量指标。Objective To explore the value of maximum standardized uptake value（SUVmax）ratio of mediastinal lymph node to primary tumor（LN/T）in dignosis of mediastinal lymph node metastasis in patients with non-small cell lung cancer（NSCLC）.Methods A total of 103 NSCLC patients underwent PET/CT and were analyzed by visual method and semiquantitative method.Primary tumors SUVmaxand mediastinal lymph nodes SUVmax were measured respectively,and then the ratio of LN/T were calculated,mediastinal lymph nodes were divided into metastatic group and non-metastatic group as the standard of the postoperative pathology results.The difference of LN/T between metastatic group and non-metastatic group was compared by independent samples t test,and the best critical value of the LN/T for the diagnosis of metastatic mediastinal lymph nodes was analyzed by ROC curve.Results A total of 346 lymph nodes were detected in 103 NSCLC patients,including 85 in metastatic group and 261 in non-metastatic group.The LN/T of metastatic lymph nodes（0.55±0.39）significantly higher than that of non-metastatic lymph nodes（0.20±0.10,P〈0.05）.Taking LN/T≥0.25 as the cut-off value,the sensitivity,specificity and accuracy for diagnosis of mediastinal lymph node metastasis were 72.94%,79.31% and 77.75%.Conclusion LN/T can be used as a index to judge mediastinal lymph node metastasis in patients with NSCLC.

关 键 词：癌 非小细胞肺 纵隔淋巴结 最大标准摄取值 正电子发射型体层摄影术 

分 类 号：R817.4[医药卫生—影像医学与核医学] R734.2[医药卫生—放射医学]