2型糖尿病患者亚临床甲状腺功能减退症与微量白蛋白尿的关系研究  

Association between subclinical hypothyroidism and albuminuria in type 2 diabetes mellitus patients

作　　者：于恒池[1] 洪旭[1] 尹洁[1] 郝雅斌[1] 段琦[1] 刘冰[1] 

机构地区：[1]首都医科大学附属北京友谊医院内分泌科,100050

出　　处：《中国医师进修杂志》2014年第34期36-38,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨亚临床甲状腺功能减退症（SCH）与2型糖尿病患者发生微量白蛋白尿之间的关系。方法纳入826例无已知甲状腺疾病且未接受相关治疗的2型糖尿病患者，评估患者的血糖控制情况、甲状腺功能及微量白蛋白尿的患病率。结果826例患者中合并SCH患者46例（5．56％，46／826），甲状腺功能正常患者780例（94．44％，780／826），合并SCH患者中女性患者的比例及体质量指数高于甲状腺功能正常患者[69．6％（32／46）比49．7％（388／780）、（26．7±4．0）kg／m2比（25．1±3．8）kCm。]，差异有统计学意义（P〈0．01）。合并SCH患者与甲状腺功能正常患者糖化血红蛋白水平比较差异无统计学意义（P〉0．05）；合并SCH患者与甲状腺功能正常患者微量白蛋白尿的患病率差异无统计学意义（P〉0．05）。结论SCH不是2型糖尿病患者发生微量白蛋白尿的危险因素。Objective To determine the relationship between subclinical hypothyroidism （SCH） and the prevalence of albuminuria in type 2 diabetes mellitus. Methods A total of 826 type 2 diabetes mellitus patients without thyroid disease were enrolled. Participants were evaluated for glyeemic control, thyroid function,and albuminuria in a cross-sectional analysis. Results Of 826 type 2 diabetes mellitus, 780 subjects were euthyroid（94.44% ,780/826） and 46 had SCH （5.56% ,46/826）. The patients with SCH had a higher proportion in women and higher body mass index compared with the patients with euthyroid [69.6%（32/46） vs. 49.7%（38g/780）, （26.7 ± 4.0） kg/m2 vs. （25.1 ±3.8） kg/m2] ,and there was significant difference（P 〈 0.01 ）. No significant difference in glycated hemoglobin and the prevalence of albuminuria was found between the patients with SCH and the patients with euthyroid （P 〉 0.05 ）. Conclusion SCH is not a risk factor for albuminuria in type 2 diabetes mellitus.

关 键 词：甲状腺功能减退症 糖尿病 2型 白蛋白尿 

分 类 号：R587.1[医药卫生—内分泌] R581.2[医药卫生—内科学]