出 处:《中国医师进修杂志》2014年第34期42-44,共3页Chinese Journal of Postgraduates of Medicine
摘 要:目的探讨影响慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭预后的危险因素。方法回顾性分析120例AECOPD合并呼吸衰竭患者,根据其治疗结果分为病情好转组(96例)和病情加重(包括死亡)组(24例),分析其临床资料及治疗措施等因素。结果两组年龄、性别构成、病程、动脉血氧分压比较差异无统计学意义(P〉0.05)。病情好转组体质量指数、白蛋白、pH值、咳嗽咳痰能力良好率、营养支持率、无创机械通气率高于病情加重组[(28.5±9.8)kg/m2比(23_3±7.4)kg/m2、(21.4±7.9)g/L比(19.3±6.8)s/L、7.23±0.20比7.11±0.17、79.2%(76/96)比25.0%(6/24)、58.3%(56D6)比33.3%(8/24)、81.2%(78/96)比62.5%(15/24)],动脉血二氧化碳分压、轻度神志障碍率、多重耐药感染率、真菌感染率、鼻饲率、激素使用时间及心力衰竭、肺性脑病、肝肾功能损害、上消化道出血发生率均低于病情加重组[(10.08±1.71)kPa比(11.98±2.03)kPa、13.5%(13,96)比58.3%(14/24)、22.9%(22/96)比41.7%(10/24)、0比29.2%(7,24)、50.0%(48D6)比75.0%(18/24)、(5.3±1.3)d比(11.3±3.8)d、8.3%(8/96)比25.0%(6/24)、13.5%(13/96)比70.8%(17124)、28.1%(27/96)比41.7%(10/24)、5.2%(5,96)比12.5%(3,24)],差异有统计学意义(P〈0.05)。结论在AECOPD合并呼吸衰竭患者中,并发症、营养状况、神志、咳嗽咳痰能力、感染情况、有效的无创正压通气、血气指标等可作为影响其预后的相关因素。Objective To investigate the risk factors of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) combined with respiratory failure. Methods The clinical data of 120 patients with AECOPD combined with respiratory failure were retrospectively analyzed. The patients were divided into disease improved group (96 cases ) and disease serious group (24 cases,including death) according to the treatment outcome. Risk factor and treatment strategies of the two groups were statistically analyzed. Results There was no significant difference in age, sex, disease course and arterial blood oxygen partial pressure(P 〉 0.05). The body mass index, albumin, pH, successful cough and expectoration rate, nutritional support rate, and noninvasive mechanical ventilation rate in disease improved group was higher than that in disease serious group[ (28.5 ± 9.8) kg/m2 vs. (23.3 ± 7.4) kg/m2, (21.4 ± 7.9) g/L vs.( 19.3 ± 6.8) g/L,7.23 ± 0.20 vs. 7.11 ±0.17,79.2% (76/96) vs. 25.0% (6/24),58.3% (56/96) vs. 33.3% (8/24),81.2% (78/96) vs. 62.5% (15/24)], arterial blood carbon dioxide partial pressure, mild eonsciousness obstacle rate, multiple drug-resistant infections rate, fungal infection rate, nasal feeding rate, hormone use time and the incidence of heart failure, pulmonary encephalopathy, hepatorenal function damage and upper gastrointestinal bleeding in disease improved group was lower than that in disease serious group [(10.08 ±1.71) kPa vs. ( 11.98 ± 2.03 ) kPa, 13.5% (13/96) vs. 58.3% (14/24), 22.9% (22/96) vs. 41.7% (10/24), 0 vs. 29.2% (7/24) ,50.0%(48/96) vs. 75.0%(18/24), (5.3 ± 1.3) d vs. (11.3 ± 3.8) d,8.3%(8/96) vs. 25.0%(6/24), 13.5%(13/96) vs. 70.8%(17/24),28.1%(27/96) vs. 41.7%(10/24),5.2%(5/96) vs. 12.5%(3/24)],and there was signifieant difference (P 〈 0.05). Conclusion Complicating disease,nutritional status, consciousness, capability of sputum exclusion, the d
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