布地奈德联合小剂量阿奇霉素对毛支后小气道病变患儿潮气呼吸肺功能的影响  

The effects of budesonide combined with small dose of azithromycin on tidal breathing lung function of children with small airways damaged after bronchiolitis

作　　者：张静[1] 

机构地区：[1]东营胜利油田中心医院,山东东营257034

出　　处：《药学研究》2014年第12期727-729,共3页Journal of Pharmaceutical Research

摘　　要：目的毛细支气管炎患儿在急性感染后炎性改变使小气道受损,出现慢性反复咳嗽喘息和运动不耐受,临床上常应用肺高分辨CT检查和潮气肺功能检查评估患儿病情转归。本文通过对比单纯雾化布地奈德和布地奈德联合小剂量阿奇霉素对患儿肺功能的影响,探讨治疗疗效,并比较两种治疗方案疗效有无差异。方法将诊断为毛细支气管炎的患儿25例,分为实验组患儿13例,在喘憋症状及肺部体征均消失后仍给予雾化吸入布地奈德的同时口服小剂量阿奇霉素联合治疗3个月。对照组12例仅给予布地奈德雾化治疗3个月。实验组及对照组均在治疗前、治疗1个月及治疗3个月时进行肺功能和高分辨CT检查,分析两种治疗方案的疗效。结果与结论 25例患儿在治疗前和恢复期的潮气呼吸肺功能相比较,VT/Kg、Ti、Te、Ti/Te、TPTEF/TE、VPTEF/VE差异均具有统计学意义。治疗1个月和3个月时的潮气呼吸肺功能比较均无统计学意义,两组患儿治疗后1、3个月分别进行高分辨CT检查,大多数患儿均有不同程度的改善。实验组及对照组两组患儿经不同的治疗方案,治疗后1、3个月的潮气肺功能VT、TPTEF/TE、VPTEF/VE两组间无统计学意义。Objective The children with bronchiolitis in acute infection after inflammatory changes in the small air-ways damaged. High resolution CT examination and tidal breathing pulmonary function test are often used in children with moisture assessment prognosis. In this paper,the efficacies were approached by comparing effects of simply nebulized budes-onide and budesonide combined with small dose of azithromycin on children＇s lung function,and to compare the efficacies of two treatment protocols with or without differences. Methods 25 cases of patients with bronchiolitis,divided into the exper-imental group 13 cases,remained to give atomization inhalation of budesonide and low dose oral azithromycin in treatment for 3 months after the asthmatic symptoms disappeared. 12 cases as the control group were only given budesonide for 3 months. Pulmonary function and high resolution CT examination of two groups were examined before treatment,and when treating a month,three months. The effects of two therapeutic schemes were analyzed. Results and Conclusion In 25 pa-tients,comparing the tidal breathing lung function in pretherapy and convalescent,the differences of VT/Kg,Ti,Te,Ti/Te, TPTEF/TE,VPTEF/VE had statistical significance,and treating a months and three months had no statistical significance. Two groups of children after treating one and three months carried out high resolution CT examination,the majority of chil-dren were improved in different degree. The experimental group and the control group children with different treatment after 1 and 3 months of tidal pulmonary function in VT,TPTEF/TE,VPTEF/VE had no statistical significance.

关 键 词：毛细支气管炎 小气道病变 阿奇霉素 布地奈德 潮气肺功能 高分辨CT 

分 类 号：R969.3[医药卫生—药理学]