心脏微血管内皮屏障功能和心肌缺血/再灌注损伤:转化医学意义探寻  

Role of Cardiac Microvascular Endothelial Barrier in Myocardial Ischemia / Reperfusion Injury: A Translational View

作　　者：齐康[1] 杨跃进[1] 

机构地区：[1]北京协和医学院中国医学科学院国家心血管病中心阜外心血管病医院心血管疾病国家重点实验室冠心病中心,北京100037

出　　处：《心血管病学进展》2014年第6期648-652,共5页Advances in Cardiovascular Diseases

基　　金：国家重点基础研究发展规划项目(2012CB518602);国家自然科学基金(81370223);北京协和医学院研究生创新基金项目(2013-1002-39)

摘　　要：微血管内皮屏障是氧、养分和代谢产物进行选择性交换的场所,对于维持心肌微环境稳态起核心作用。微血管通透性增加可促进白细胞跨内皮迁移、组织水肿和炎症反应。微血管通透性增加与心肌再灌注损伤程度不仅存在显著的正相关,还有生物学机制上的密切关联。虽然现有的再灌注治疗和公认的辅助治疗措施能够有效降低急性心肌梗死患者的病死率,但该部分患者仍存在再灌注损伤的剩余风险,调节微血管通透性的转化医学研究成果有望进一步改善患者预后。The microvascular endothelial barrier has a key role in maintaining myocardial microenvironment homeostasis through allo- wing for the selective exchange of oxygen, nutrients and metabolites between the blood and surrounding tissues. An increase in endothelial permeability promotes neutrophil transendothelial migration, myocardial edema and inflammation. The increase in endothelial permeability is associated with myocardial ischemia/reperfusion injury both statistically and biologically. Although mortality of patients with acute myocardial infarction has been greatly reduced under current reperfusion therapy combining with accepted adjunct therapies, myocardial ischemiafreper- fusion injury remains residual risk. Translational medicine studies on microvascular permeability regulation may provide hopeful resolutions for further improvement of prognosis in these patients.

关 键 词：心肌再灌注损伤 微血管通透性 内皮细胞 心肌梗死 转化医学 

分 类 号：R542.2[医药卫生—心血管疾病]