钙增敏剂对心肌钙稳态的影响  

Effect of Calcium Sensitizer on Calcium Homeostasis of Cardiomyocytes

作　　者：薛祚臣 单兆亮[1] 

机构地区：[1]解放军总医院心内科,北京100853

出　　处：《心血管病学进展》2014年第6期653-656,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(30772886)

摘　　要：心力衰竭是目前人类主要的死亡原因之一,以左西孟旦为代表的钙增敏剂作为新一代强心药,目前被广泛应用于急性失代偿性心力衰竭的治疗,但是临床对其安全性以及远期预后的报道存在较大差异,原因可能与其改变心肌细胞钙缓冲能力,从而影响钙稳态的药理作用有关。现对钙增敏剂对心肌钙稳态的影响做一综述。Heart failure is a primary cause of death. A new generation of inotropic agents--calcium sensitizer, now is widely used in acute decompensated heart failure treatment, but there is a big difference in the reports of its clinic safety and long-term prognosis. The rea- son may be related to the pharmacological effects of the changes in intracellular calcium buffering and affecting calcium homeostasis. This ar- ticle conducted an overview about the effect of calcium sensitizer on myocardial calcium homeostasis.

关 键 词：心力衰竭 钙离子增敏剂 钙稳态 

分 类 号：R541.6[医药卫生—心血管疾病]