获得性Brugada综合征研究现状  

Current Research in Acquired Brugada Syndrome

作　　者：段慧[1] 郭良敏[1] 李锐[2] 何川[1] 

机构地区：[1]成都市第三人民医院心内科,四川成都610031 [2]成都市第三人民医院护理部,四川成都610031

出　　处：《心血管病学进展》2014年第6期736-740,共5页Advances in Cardiovascular Diseases

摘　　要：获得性Brugada综合征是一种除了遗传因素以外还与后天因素有关的离子通道疾病。新近的研究又发现了许多与发病相关的基因和细胞电生理机制,如编码甘油-3-磷酸脱氢酶样基因、心脏传导延迟等。根据发病原因将获得性Brugada综合征分为多种类型。获得性Brugada综合征是部分猝死的真正原因。目前的治疗药物仍首选奎尼丁,而埋藏式心脏转复除颤器和射频消融逐渐成为治疗获得性Brugada综合征主要的手段和方法。Acquired Brugada syndrome is an ion channel disease that is associated with both genetic and acquired factors. Recent studies have indicated that a number of genes and cellular electrophysiological mechanisms are involved. Acquired Brugada syndrome is di- vided into several types according to its etiology. Acquired Brugada syndrome is the real reason which lead to sudden death. Quinindiun is still the priority therapies to treat acquired Brugada syndrome, however, implantable cardioverter defibrillator and radiofrequency ablation treatment is gradually more applied by clinical treatment.

关 键 词：获得性Brugada综合征 心脏性猝死 离子通道 

分 类 号：R541.78[医药卫生—心血管疾病]